Home › Forums › Main Forum › Experts Corner › Viral Load and SVR › HCV Viral Load and Speed of Decline Do Not Predict Cure

Viewing 7 posts - 1 through 7 (of 7 total)
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  • 5 March 2016 at 3:51 am #13326
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he’d failed only to go on to clear at 3 months post tx – Interesting. Is there ‘any’ sort of pattern appearing?

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    5 March 2016 at 7:40 am #13342
    Avatar photoTina-Hill-facebook
    • Guardian Angel
    • ★★★★★
    @tina-hill-facebook

    Love this article

    Yes LG I too wonder whether the current EOT and SVR 4 result for Redemption are mirroring what we read in the conclusion of this study, time will tell.

    Its reassuring for me to have read this as I am still detected <12 upon the EOT (Abbott Real Time Assay). I am hopeful that I too will follow the trend as suggested by the author. If that is not the case at my EOT + 4week VL then I will retreat using a alternative DAA regime with an extended tx period from my first round.

    Interesting ride ahead awaits me.

    SVR 24

    5 March 2016 at 10:23 am #13349
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    yes no panic :)

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    5 March 2016 at 10:35 am #13353
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara
    LondonGirl wrote:

    Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he’d failed only to go on to clear at 3 months post tx – Interesting. Is there ‘any’ sort of pattern appearing?

    Yes if you see the US forums there are many examples of this kind of pattern where detected EOT and at 4 weeks EOT but got SVR 12

    Even for the doctors these are new drugs and their experiences are limited. The article is a year old but glad its here just reduces the anxiety and panic.

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    7 March 2016 at 2:28 pm #13466
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Just read this (Tina) xx

    http://hepcukforum.org/phpBB2/viewtopic.php?p=173731#173731

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    7 March 2016 at 3:23 pm #13469
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    http://forums.hepmag.com/
    Many many stories like this there

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    7 March 2016 at 6:34 pm #13474
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Had a chat with my friend previously mentioned, he said he was Detected 15 at EOT , then a few weeks post EOT VL rose to 50, but at week 12 post tx he was UND.

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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