Good morning Beaches
I’m guessing you’re swimming in the 20 degree water soon lucky duckie it’s brrrrrr here woke me up!
Re your query I do recall that this was addressed a while back maybe by James
Praps a mod can find the info and bump the thread so we can read it
I hope I am right lol
Maybe it’s an actual conversation I am recalling
Anyway it’s an important question so let’s wait for the answer again xxx
A

Undetected means too low to measure as in <6 or <8 depending on the test and I'd it is plasma or serum being tested. It does NOT mean zero, thus undetected people relapse.

Beaches, all I can add, is to make sure you’ve treated yourself with the best appropriate DAA’s for your genotype, fibrosis & past treatment history.
Once you’ve done that, “CROSS YOUR FINGERS”
Like us all on here, hope & pray for the UNDETECTED SVR 12 & 24.

As Gaj says you have odds 30:1 in your favour. If I was a betting man and you were a horse I would definitely have money on the nose for you! Relax, it will almost certainly be fine, and even if you did relapse we have 1 more good treatment available now, with the promise of another 3 in the next few months. Even if you managed to fail all of those there will be new options.

So….
Undetected and “Negative” are the same thing?

I wasn’t planning on doing SVR24
Is this necessary?
I was told SVR12 is it by my hospital
My GP and I will follow the protocol suggested here
I’m sorry to hijack your thread here Beaches but I noted this issue and I think others may also want to know the best lab protocols for us going forward
Ty for bringing this up Michael
So please can I have feedback re doing a test for SVR24
Ty
Ariel [/quote]

Hi Ariel,
in my case the SVR 24 is because I was on 24 week treatment , G1a, F3 / 4 & relapsed on peg interferon / riba.
I’m sure I’ll be excited if my SVR 12 results come in as undetected but the SVR 24 will be the icing on the cake.
I may also have a SVR 48 just for peace of mind.

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Understanding SVR – Why don’t we call it cure? 2 months 4 weeks ago
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SVR means Sustained Viral Response.

When we stop the medications if there is no virus left you will remain undetected and this is SVR.

Undetected at 4 weeks post finishing – SVR4 – predicts a 96% chance of permanent cure

Undetected at 12 weeks post finishing – SVR12 – predicts a 99% chance of permanent cure

Undetected at 24 weeks post finishing – SVR24 – predicts a 99.9% chance of permanent cure

So if you finish treatment and there is virus left it will grow back, your viral load will increase again and you relapse.

If we can not detect any virus you are at SVR and the longer that remains the case the more certain we are it is permanent.

Patients reaching SVR24 post interferon/ribavirin have remained virus free for 18 years of follow up.

With DAAs we don’t have that length of follow up but basically with no drugs to hold the virus off if it is still present it grows back, and if it is not still present it can not grow back because it is gone.

You can be confident at SVR4, really confident at SVR12 and pronounce yourself cured at SVR24. There is a strong suspicion that anyone relapsing after SVR24 is not a relapse, but rather a reinfection because if the virus has had 24 drug weeks to grow back and has not…..
YMMV
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So do you recommend being tested at 24 weeks as well and 4 & 12?
Lives in Bendigo, Victoria
No prior treatment Genotype 1b Fibroscan 0 (only showed a bit of a fatty liver) Diagnosed in February 2015 Currently on my last week of treatment taking led/sof Last LFT normal
Insomnia the only side effect
Undetected at 4 weeks
SVR4 – undetected – all bloods good and GP very happy
SVR12 bloods to be done at end of April 2016
SVR12 – undetected!!!
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Yes, it’s probably not a bad idea but unless you were one of those asymptomatic people with normal liver functions if you did relapse you would expect to feel sick and this to be obvious on your liver function tests.

After SVR24 maybe check it in a year to satisfy paranoia and declare yourself cured beyond all reasonable doubt.
YMMV
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Forum Main Forum Experts Corner Viral Load and SVR Understanding SVR – Why don’t we call it cure?