Twinvir versus Lesovir-c

This topic has 21 replies, 8 voices, and was last updated 9 years, 2 months ago by Enkel.

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9 October 2015 at 6:44 pm #2079
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
Hi All,

Anyone any information about these two generic harvoni: Twinvir versus Lesovir-c

Which is better and tested?

I appreciate any info?

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 11:41 am #2091
tweakmax
- Topics: 18
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- Total: 256
- Guardian Angel
@tweakmax
I am guessing they are equally good

The chinese are going to use beximco meds soon

http://bbs.kangantu.com/forum.php?mod=viewthread&tid=122&extra=page%3D1
10 October 2015 at 12:14 pm #2092
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
THANK YOU

I have a friend of a friend in Banglandeshi. And I dont know if 12 bottles of Lesovir that is 12 week are big for customs. They have a hudge packing.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 12:45 pm #2093
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
If u managed to buy, let us know

Hope your mother in law get well soon
Let us know her lab results
10 October 2015 at 12:53 pm #2094
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
I am another guy, i need it for myself. I am F1 and I wonder why I have ALT fluctuating from 40-80(relatively low) while i have a viral load 5 million. Where this hudge viral load replicates? Maybe in my nervous system as i suffer anxiety, depresion. That why I want to treat.

Thanks

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 1:04 pm #2095
Dr James
- Topics: 264
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- Guardian Angel
@fixhepc
We have tested Twinvir. Happy to test Lesovir-c if anyone wants to send me a tablet.

Anyway go here: http://fixhepc.com/blog/item/16-testing-provisions-patient-safety.html and search the NMI Certificates for Twinvir.

Here’s one doc: http://fixhepc.com/images/coa/NMI-NATA-Sofosbuvir-Certification.pdf

And it says:

The 1H NMR matches that for a sample of sofosbuvir extracted from tablets
of Twinvir™, and the spectrum reported in J. Med. Chem., 2010, 53, 7202-
7218.

YMMV
10 October 2015 at 1:21 pm #2096
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
Hi Doctor,

In a few words, the twinvir is good quality?

Lesovir uses solid solid dispersion for the component ledispavir.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 1:25 pm #2097
LondonGirl
- Topics: 16
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- Guardian Angel
@londongirl
and the Ledipasvir used, is this tested? Thanks

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
10 October 2015 at 1:35 pm #2098
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
Hi Doctor,

Where to send the tablet Lesovir-C? What address?

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 2:27 pm #2099
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
My bad
I think I have brain fog
I mistook u for the guy whose mother (or mother in law) need the meds
Sorry…..
10 October 2015 at 2:30 pm #2100
chertes
- Topics: 0
- Replies: 12
- Total: 12
- Acolyte
@chertes
what about the amount of ledipasvir in a tablet of Twinvir ?
it is the right amount ?
thank you
10 October 2015 at 2:39 pm #2102
Dr James
- Topics: 264
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- Guardian Angel
@fixhepc
You could send it to:

Dr Greg Tarrant
Senior Synthesis Chemist, Chemical Reference Materials
Ph: +61 2 9449 0180 | Fax: +61 2 9449 0292
greg.tarrant@measurement.gov.au
National Measurement Institute
105 Delhi Rd, North Ryde, NSW 2113, Australia

Normally it would be:

Dr Stephen Davies
Team Leader, Chemical Reference Materials
Ph: +61 2 9449 0183 | Fax: +61 2 9449 0292
stephen.davies@measurement.gov.au
National Measurement Institute
105 Delhi Rd, North Ryde, NSW 2113, Australia

But he is away for 3 weeks.

The National Measurement Institute did our testing.

YMMV
10 October 2015 at 2:42 pm #2103
Dr James
- Topics: 264
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- Guardian Angel
@fixhepc
Yes, that is on the blog http://fixhepc.com/blog/item/16-testing-provisions-patient-safety.html too:

http://fixhepc.com/images/coa/NMI-NATA-Ledipasvir-Certification.pdf

The 1H NMR matches that for a sample of ledipasvir extracted from tablets of Twinvir™.

YMMV
10 October 2015 at 9:05 pm #2117
Rasel Rahman
- Topics: 0
- Replies: 7
- Total: 7
- Novice
@rasel-rahman
Dear Enkel,
Twinvir. has small package. Each box contain six tablet, thus you need only 14 box. You can tell your friend to contact with me. I can help him this.
Phone: +8801730352074.
12 October 2015 at 1:40 pm #2169
chertes
- Topics: 0
- Replies: 12
- Total: 12
- Acolyte
@chertes
i dont know where i read that someone send Lesovir-c for testing
an update on this will be helpful ,it is arrived ?, tested ?….
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