Zepatier + Sofosbuvir trial effective for 'hard to treat' GT3s

This topic has 4 replies, 3 voices, and was last updated 7 years, 11 months ago by Johnboy.

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16 November 2016 at 3:52 am #24311
Gaj
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- Guardian Angel
@gaj
Some promising results from a trial for ‘hard to treat’ genotype 3 patients with cirrhosis + treatment experience. Hopefully this C-ISLE clinical trial will lead to inclusion of a Zepatier+ treatment as another recommended (or at least off label) option for GT3.

http://www.infohep.org/Grazoprevirelbasvir-sofosbuvir-highly-effective-for-hard-to-treat-genotype-3-hepatitis-C-patients/page/3099138/

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
16 November 2016 at 4:12 am #24312
beaches
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@beaches
Great news, Gaj, is a generic version available? I guess that’s the $100,000 question

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
17 November 2016 at 12:44 am #24322
Gaj
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- Guardian Angel
@gaj
Hi beaches,

You want generics two days after we find out it works?!

At the moment it’s news of a possible option for GT3s for whom current treatments aren’t always very effective. Although in countries where branded Zepatier is already available GT3 patients needing to retreat could have a discussion with their specialist about supplying their own generic Sofosbuvir.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
17 November 2016 at 1:15 am #24323
beaches
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- Total: 760
- Guardian Angel
@beaches
Hey Gaj,
For myself it makes no difference, but for you and others in the same boat why yes I want it yesterday

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
5 December 2016 at 6:53 pm #24600
Johnboy
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- Guardian Angel
@johnboy
So……. I find Elbasvir on the Mesochem search function but no Grazoprevir.

Does anyone know anything. I read a link about Beacon being the first to copycat it but so far it does not look like the link has the right info. I’m still looking but I reckon James already knows the answer.

G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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