Thank you for this info , Dr.
Is mechanism of action of this medication such that it is benefitial for cholestasis symtoms only or is it good for liver health in general ?

According to Drugs.com, ademetionine (generic) is SAMe, and SAM-e.

https://www.drugs.com/international/ademetionine.html

Just did a quick google search. It appears SAMe is fairly cheap and widely available as a nutritional supplement (no prescription required) in the US.

Hmmm….

Thanks for the thoughtful caution and information, Tommy.

Honestly, I’m not one who believes everything I read on the internet. On the other hand, I believe that contempt prior to investigation is bad policy (for me).

SAMe looks like it is genuinely worth investigating.

When I learned about Chlorcyclizine, I researched that as well. I’ve got a two month supply (unused) sitting in the original shipping box in the closet. Going a bit off topic here – at my own risk I gave it a try for a week.

Like Ademetionine, Chlorcyclizine is available OTC here in the US. Turns out Chlorcyclizine is very strong stuff, and I decided at the end of one weeks personal trial, the drowziness and horrible aftertaste were more than I was willing to put up with – especially since I was already well into a 12 week course of generic Sof/Led therapy.

Did the week on Chlorcyclizine help? I really don’t know. Probably not, but maybe? I do know that after 12 weeks of generic Sof/Led therapy I am officially “cured”.

Having lost entire joints to Hep C, and having borne the associated expenses, the $36 a month for 800+ mg of SAMe doesn’t seem all that expensive. So, I’ll look into it

At this point, (one man’s non-medical layman’s opinion) I would advise against trying the stuff (Ademetionine) while on DAA therapy since we don’t know about possible interactions with DAAs.

I’m sure Dr. Freeman will be along with some actual medical guidance on this.

ETA: Here’s a link to an interesting article on SAMe : http://www.journal-of-hepatology.eu/article/S0168-8278(12)00409-6/fulltext