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Viewing 9 posts - 1 through 9 (of 9 total)
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  • 19 October 2015 at 11:14 am #2477
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    I see that people prefer Indian generics that are licensed by Gilead. I think that Gilead gives them only permission to produce. Gilead does not invest a bit for the quality of Indian generics. Where Indian Pharma takes the APIs?

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    19 October 2015 at 3:23 pm #2485
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Bangladesh will be the first country to be able to prove the clinical quality of their generics in the only way possible, via a 3000 person clinical trial the tracks the outcome for taking that specific formulation.

    YMMV

    19 October 2015 at 4:34 pm #2488
    Avatar photoSirchinenge
    • Guardian Angel
    • ★★★★★
    @sirchinenge

    There is no Bangladesh V India.

    When Greg started he had contacts in China and India hence you bought
    from either one depending on Geno Type.

    Early on, Greg had no contacts in Bangladesh he had no safe way to offer Twinvir.

    The Buyers club came along and offered to buy direct from China they now have the
    trials offering other products.

    Honestly, I see no reason to get bogged down in Gilead’s agreement with any
    Generic maker in India.

    Sob/Dac from Oct 29 2015
    Geno 1b
    Fiberscan 9.9 Pre treatment
    Fiberscan 7.4 week 10
    VL 1.3 million pre treatment
    Week 2.5 VL 96
    Week 5.5 VL 17
    Week 10 VL UD
    SVR 3 UD
    SVR 16 UD
    Cured:
    All liver functions in normal ranges.

    19 October 2015 at 6:47 pm #2491
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    The idea is that some people wait for Hepcinat LP while they have at the moment Twinvir. Is the product of Natco better than the one of Incepta?

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    19 October 2015 at 7:02 pm #2493
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    This is a fair question – Is there a difference in medicines or is it just patients feeling more ‘secure’ with the official generic?

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    19 October 2015 at 7:08 pm #2494
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    Does Twinvir uses solid dispersion?

    Ledipasvir exhibits low, but pH-dependent, solubility and high apparent permeability (BCS class II). It is
    susceptible to the influence of gastrointestinal pH and fed state and so an amorphous spray-dried
    dispersion of LDV (LDV-SDD) was developed in order to mitigate these food effects. LDV-SDD is an
    amorphous solid powder. It is hygroscopic and photosensitive, but physically and chemically stable for up
    to 6 months if protected from light and moisture in a sealed container. The physicochemical properties of
    LDV-SDD are amenable to formulation in a solid oral tablet.
    http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/003850/WC500177996.pdf

    Edit: this technology used in Harvoni or maybe in Lesovir-C does not change a thing. it is just a marketing.

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    19 October 2015 at 9:06 pm #2495
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    I don’t really understand what you are saying Enkel.
    Sorry – can you simplify?

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    19 October 2015 at 9:15 pm #2496
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    Solid dispersion used for ledipasvir does not increase the effectiviness of medication being it harvoni or any drug claiming the solid dispersion.

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    19 October 2015 at 10:21 pm #2498
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Ah , so someone was saying that was a problem but it’s not?
    I see.

    It’s good to have some clever people on here :)

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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