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  • 1 August 2017 at 10:59 pm #26663
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Here is some data about adding sofosbuvir to salvage patients who failed either Zepatier, or Viekira.

    http://www.aidsmap.com/Treatment-intensification-with-sofosbuvir-permits-cure-after-failure-of-previous-HCV-treatment/page/3014995/

    YMMV

    2 August 2017 at 5:34 pm #26664
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I think I heard that Zepatier and Sof works great for type 3’s. If I’m not mistaken, they achieved 100% of failed prior responder type 3’s.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    3 August 2017 at 3:15 am #26669
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Splitdog,

    Here is the EC50 in GT3 for all the drugs. ABT-493/ABT-530 are Maviret (G/P) and GS-9857 is Voxilaprevir.

    GT3-EC50-2-3.png

    YMMV

    3 August 2017 at 5:05 am #26671
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    What is the “pM” and “nM”?

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    3 August 2017 at 5:43 am #26673
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Splitdog,

    pM (pico Moles) and nM (nano Moles) are units of concentration. The smaller the number the stronger the drug, because you only need a sniff of it to work.

    YMMV

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