I don’t know if this is normal, but so far I’m feeling no side effects. I think that the first two pills seemed to cause an increase in inner body temperature, but heck I may have been imagining that. I did my normal 1 hr plus work out, mowed and edged the lawn, spent an hour tending to my extensive rose garden (76) and a few other things that came up. I have been consuming at least 72oz of water daily and trying to get at least 6 hrs. sleep nightly. I’ve, so far, had no reduction in energy so I feel blessed. Epclusa does seem to have few major side effects, but every body is different. Good luck to all from Oregon, USA