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TOPIC: compounding Daclatasvir yourself

compounding Daclatasvir yourself 3 years 6 months ago #3393

  • cole
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Hey,

I ordered the torpac size 0. Can i fit 400mg sofosbuvir in size 0 capsules?

thanks.
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compounding Daclatasvir yourself 3 years 6 months ago #3395

  • mgalbrai
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I don't know. 400 mg, tightly packed leaves about 1/16 inch remaining in a 00 cap. No room for the 90 mg ledipasvir-so I make 1 sof, 1 led. I think you could get 490 mg in two 0 sized caps.
You can make it work.
Mike
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 3 years 6 months ago by mgalbrai. Reason: Typp
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compounding Daclatasvir yourself 3 years 6 months ago #3397

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Maybe put 200 sof and 45 led in each cap. Just take two a day. That way they are all the same.
Mike
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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compounding Daclatasvir yourself 3 years 6 months ago #3402

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Size chart
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compounding Daclatasvir yourself 3 years 6 months ago #3403

  • Life
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Hey! 400mg in a 0 capsule is not possible to me, depends on how you're going to fill them but...huhmn...no...not easy at all...Daclatasvir slides more like sand, sofosbuvir is much thicker!cole wrote:
Hey,

I ordered the torpac size 0. Can i fit 400mg sofosbuvir in size 0 capsules?

thanks.
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compounding Daclatasvir yourself 3 years 6 months ago #3404

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I don't know if it has to be equal, as long as you take the right amount of both in you it's ok...245 mg per capsule, it's possiblemgalbrai wrote:
Maybe put 200 sof and 45 led in each cap. Just take two a day. That way they are all the same.
Mike
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compounding Daclatasvir yourself 3 years 6 months ago #3406

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Thank you. I hope they haven't shipped, will try to switch it tomorrow for 00. I live close to torpac, will go and exchange it.
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compounding Daclatasvir yourself 3 years 6 months ago #3407

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The Profunnel works great, but you can just fill the large, bottom portion. I imagine, from my experiece, you could tighly pack 420-430 mg of sofosbuvir in it. When you snap the smaller top portion on, there will be some space. So its not completely full. I don't think the funnel is made to work any other way, but I don't know that for certain.
Mike
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 3 years 6 months ago by mgalbrai. Reason: Typo
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compounding Daclatasvir yourself 3 years 6 months ago #3411

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My first patient on generic APIs is now past SVR12. His method was simple - weigh on a teaspoon, swallow with water. Capsules are a convenience mechanism, as are tablets. Don't over think it.

If you want to use filler for volume based filling of multiple capsules simultaneously use lactose from the baby section of the chemist and grind the API and lactose together in a mortar and pestle to equalise particle size and ensure a uniform mix.
YMMV
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