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GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV)

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GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16343

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Hi Everyone

Great News Today … I finally got back by week 4 Vial Load Test.



All of my week 4 tests results are back now. I was thrown a curve ball initially with an unexpected high fasting glucose level. It concerned me and I was worried it may have adverse effects on the efficacy of the SOF + DCV. I was feeling confident prior to this.

I was also feeling the pressure of not letting the GT2 team down …especially considering that I had the audacity to call myself GT2 and Dr Freeman stated that he has 100% for SOF + DCV in GT2 so far.

fixhepc.com/forum/gt2/1000-2b-juen-start...ndetected.html#16057

Anyway, I can happily say that I haven’t ruined the batting average. Dr Freeman, you still have a perfect strike rate. I know I’m only on first base, but I’m confident of making it home to SVR12. Thanks Greg Jefferys for taking the time to explain all of my treatment options, considering your busy schedule at the time, and then making the rest of the process a breeze. I will always be internally grateful to you and Dr Freeman. This has changed my life!


1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
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The following user(s) said Thank You: Joy, Ariel, Hazel

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16345

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Sorry about the Freudian Slip

I will always be internally grateful

I meant, that I will always be eternally grateful ...

My internal liver will also be forever indebted to you guys ... :lol:
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
The following user(s) said Thank You: Joy, Ariel, Hazel

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16346

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Excellent news, GT2.
It's good to see your vial load is empty now ;)
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
The following user(s) said Thank You: Ariel, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16353

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Ariel wrote: That's a SLAB that wave you posted surely not Margies where is it? Its a towie wave for sure. The ripples were head high yesterday here and fun small barrels I don't do tow in myself hahaaaa geez your posts make me smile GT2
Actually that slab you posted is a good metaphor for interferon erghhhh. I would defs wipe out and I did on peginf lol!!
Have a look at my avatar that's a couple of weeks ago we are just getting swell after swell in Vicco.
Hey, Tasmania..... If you are in Hobart head down to Shippies because the fellas are towing there like huge waves
I'm fascinated by tow in surfing it's another league and they seriously risk their lives have a listen to Ross Clarke Jones on it or Greg Noll of course
See what's happening GT2 once I am wound up on surf I cannot stop! Argh
Anyhoo the thing is how much can you take in wiping out? Surfer Today explains it:

" Big waves are surely heavy. If you want to get an overall weight for your specific wave, you can roughly memorize that a cubic meter of water (1000 liters) weighs one metric tonne (1000 kilograms). How about that?

Example: a 33-foot (10-meter) wave with a falling lip that is 66-feet (20-meters) wide will mean that, if you wipeout, you'll feel the equivalent of 410 tonnes (410000 kilograms) over your body. That's the weight of 488 Volkswagen Beetles (1967 model)!

Another example from the average surfer's perspective: imagine a 20-inch (50 centimeter) thick wave lip, only 3.2 feet wide, in a summer three-foot wave. Total weight? A solid 500 kilograms (1100 pounds)."

My preference is 3-6 foot and they are more than capable of holding me down if the swell period is over 14 seconds! I don't wipe out much but I feel it when I do
Love the pic GT2

Ariel

Hope this next doesn't offend anyone...

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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The following user(s) said Thank You: Ariel, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16358

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Good one Beaches ... no offence taken here.



I'm not too sure what sort of degenerate misfit, or mental defective, Ronald is ... :lol: :P ;)

Ya gotta have a laugh ... it lightens the load ...
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
Attachments:
The following user(s) said Thank You: Ariel, beaches

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16362

Metaphors be with you!!
mike
This email address is being protected from spambots. You need JavaScript enabled to view it.
forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: Ariel, beaches, Hazel, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16366

Good 4 U GT2 :+1: :+1:
Oh yeah, I want in on the hijacking of yer post ;) sorry man :evil: hey beaches! Hey Ariel! The following is for you ... :lol:

Sharks ... We don't need no stinkin' sharks!
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
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The following user(s) said Thank You: Ariel, beaches, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16367

Oh, hey GT2, you've been hijacked :lol:

GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
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The following user(s) said Thank You: mgalbrai, Ariel, beaches, Hazel, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16369

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Congrats GT2 :woohoo: So glad you didn't ruin our batting average :P just kidding....we'll keep you in the line up, might even move you up in the batting order...cuz your batting 1000 from now on :+1: :+1: #flower #flower
GT2b diagnosed 10/2015
since: unknown
11/20/15 VL= 214,070
12/4/15 ALT=18 AST= 24
1/16/16 started sof/dac
2/13/16 @4wks VL=UND ALT=13 AST=22
3/12/16 @8wks VL=UND ALT=10 AST=18
4/9/16 EOT VL=UND ALT=11 AST=19
9/23/16 SVR24 ALT=11 AST=22
The following user(s) said Thank You: Matt-Kenney-google, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16380

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FANTASTIC NEWS GT2!

HONK HONK!


#woohoo!
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.
The following user(s) said Thank You: Matt-Kenney-google, GT2

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16386

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Thanks Agent 86.

I was initially given the old curve ball trick :angry: … and I missed it by that much :whistle: … KAOS called me in the first time to tell me the bad news, let me dwell on it for a few days, and then called me back for the good news. :cheer: I’m just happy they didn’t use the cone of silence. :P
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
The following user(s) said Thank You: Matt-Kenney-google

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16387

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Hi Matt

Great cartoon!

Sometimes our so called “democracy” feels like a dictatorship … especially when the tail wags the dog to such an extent that big Phama dictates to governments and then avoids paying its fair share of corporate tax by funnelling the majority of their profits into low taxed countries, like Ireland (12.5%). :angry:




I hope that you are sailing through your first few days of treatment.

Best Wishes
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
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The following user(s) said Thank You: DrJames, Ariel, Matt-Kenney-google

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16388

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Hi CC2B

I have to thank you from the bottom of my heart, and the other GT2s on this forum who have taken SOF + DCV, for giving me the confidence to step up to the plate and have an almighty swing at this difficult to hit HCV virus. I noticed that you, and the others, hit it well out of the park first time and every time. Based on that, I decided to join your team (sorry about the self invite ...)

If it wasn't for you guys, like a blind fool, I would have followed the standard GT2 recommendation of SOF + RBA and probably been sick as a dog for 3 months or so. I really think that the “experts” who make these recommendations need to urgently reconsider their GT2 guidance.

I really don’t deserve being promoted up the batting order … I’m just happy backing up all the GT2s before me … I’m merely standing on the shoulders of giants. Thanks guys!

Cheers

GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
The following user(s) said Thank You: CC2B

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16389

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Hi Joy

Thanks for Honking.

Here’s a good old fashioned Aussie TOOT! TOOT! back.

To paraphrase the Wriggles, Toot Toot, Chugga Chugga from the Big Red Car …

Best Wishes

GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)

GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) 6 years 10 months ago #16390

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Hi Ariel

To answer your earlier question, I was told this arvo that the massive waves posted above and below were breaking only 200 meters out from the beach at Walpole, Western Australia.




Been for a surf today?

Cheers

GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
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The following user(s) said Thank You: Ariel
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