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TOPIC: REDEMPTION 4 - Epclusa - 12 week course - Experience

REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 10 months ago #23482

  • DennisP
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Hello,

I'm new to this forum and I am about to order a 12 week course of Redemption 4 - Epclusa generic (Sofosbuvir & Velpatasvir).
I have no chrirosis and my fibroscan is 5.6.

Has anyone tried this medicine?

Also does anyone of you know the difference between Redemption 2 and 4 in terms of treatment effect for the genotype 3?


Thanks!
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 10 months ago #23484

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Hi DennisP and welcome. :)

If you read the article that Dr Freeman linked in the following post you will see that it states:

"In patients with HCV gentotype 3, the new drug did better in sustained virologic response and “hints of lesser harm” in that there were fewer reports of adverse events."

It doesn't state how much better the SVR rate is but from what I have read elsewhere probably in the order of a couple of percent.

fixhepc.com/forum/hcv-research/1348-velp...ier-drugs.html#22381
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 2 years 10 months ago by Gaj.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 10 months ago #23487

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Thank you Gaj. I did read that article and yes there's the isn't much else out here. It would be great to see if there's anyone out here with the similar diagnosis and has tried this medecine.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 10 months ago #23689

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Hi!
I was gen 1b and the results are being updated in my signature. I'm 1m into treatment.
I read of several (>5) gen 3 people who were cured with sofosvel on hcv.ru Probably no difference btw the two generics (sofosvel and panovir - which I'm being cured with now).
Otherwise, check the trial results. On sof/vel and on pibrentasvir/glecaprevir.
As far as I see, there is no reason to defer treatment as many retreatment options are coming - and you never know what works.
If I were you I'd sof/vel. And if were unsuccessful, retreat with abbvie's combination. However, read everything carefully. Individual experience does not count. Trial data is a bit more reliable.
There is few data and you can just read through and see what works for you.
Wish you best luck with your treatment.
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 2 years 10 months ago by vitrus.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 10 months ago #23693

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Hi Vitrus and thanks for your reply.

Great to hear about other successfully treated patients.

I have started the treatment with (Sofusvel Sob/Vel from Beacon) almost a week ago on 8th of February. From what I read the results are showing after 4 weeks. I have a doctors appointment on 3rd of March (just over 3 weeks) so hopefully there will be some good news.


Thanks again,
D
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 9 months ago #23715

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Good Luck on treatment Dennis. I've only heard of good success rates with Sof/Vel.
Where do you live? I'm in USA and thinking about ordering from Beacon also.
Thanks
happi
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 9 months ago #23718

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Thank you! I live in London. Good luck! I will make sure to post here after I've been to doctor and seen the results.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 6 months ago #24651

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I am genotype 3A and on generic Epclusa. I plan on taking it the full 24 weeks just to be sure it is gone, although I know results have been shown to be effective in treating it not as long. You have already finished your 12 weeks by now. Your post was 4 months ago. Hope to hear how you are doing.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 2 months ago #25281

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Hello,

I am new on this forum and start my therapy on Sun Oct 24 th,which is Generic EPCLUSA for 12 weeks,
GT 3



Is there anybody here who finished therapy already with GT 3?
Thank you and good luck for everybody
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 2 months ago #25284

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Hi JoannaCH and welcome,

Firstly congratulations on starting your treatment. I had G1a so my treatment was a little different to yours but thankfully these different medications are leading to the same outcome - the eradication of the virus.

There are G3s who have successfully treated with Epclusa and you'll find one will hop on the forum soon to share their experiences on that particular medication.

In the meantime we're with you. Roll on October 24th! :woohoo: :woohoo:
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 2 months ago #25336

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Hello. I am not very good at forums but I wanted to share my experience. I was diagnosed with hepatitis C Genotype 3 in March 2017 which was a massive shock that this had gone undetected for 30 years!!! I became extremely anxious having to break the news to my family and particularly my 19 year old son who had to be tested as I could have passed this on to him whilst I was pregnant. Thank god he was negative. Treatment for Hep C Genotype 3 is not funded in New Zealand unless you are nearly dead! My specialist referred me to these wonderful people at FixHepC whom I am extremely grateful to. A huge thanks to all the admin staff and of course Dr James Freeman. I have also been lucky to have wonderful support from my close friends and family.

I was started on a 12 week course of Sofosbuvir and Daclastavir. Initally it was ceased by NZ Customs for two weeks and I was charged customs, duty and GST! Unfortunately, 10 weeks into treatment I had a Fibroscan which showed a liver stiffness of 29.3 consistent with cirrhosis. Another shock for someone who has never consumed alcohol. How naive of me to think I have had this virus for decades and it wouldnt leave any damage. I was very positive that I would complete the 12 weeks treatment and I would be fine. Subsequently I contacted Dr James Freeman who suggested a change to my medications to Sofosbuvir and Velpatasvir to complete a total of 24 weeks of therapy, i.e. 16 weeks of Sof/Dac and 8 weeks Sof/Vel. My second lot of treatment got through Customs without any problems. Recently I had a CT scan which has confirmed the presence of cirrhosis. I have just completed treatment last week. In NZ they do not test viral loads throughout treatment only SVR at 3 months after treatment so after six months of treatment I have changed specialist and I am stoked my bloods came back negative for Hep C last week so fingers crossed it will stay this way!! The only side effect I experienced was extreme fatigue - so so tired I had to cut my hours down to 20 hours a week. I feel like I have been hibernating for six months and binge watched so many Netflix series I will never have to watch TV again! Since stopping treatment a week ago my energy levels have almost returned to normal.
Geno 3
Diagnosed March 2017 (poss contracted 30 years ago)
ALT 399 GGT 296 VL 1.8mil
Started 12 weeks Sov/Dac
Additional 4 weeks Sov/Dac
Currently Sov/Vel for 8 weeks
Fibroscan 29.3kpa after 12 weeks Sov/Dac
CT Scan 11/09/17 Cirrohsis
18/8/17 ALT 107 GGT 71
20/9/17 ALT 69 GGT 67
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 2 months ago #25337

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Hi sixtieschild,

Congratulations on your results. :woohoo: :woohoo: I know how wonderful it is to hear the news that it's a great big negative.

Thanks for sharing your story. It might be the one that tips the balance for someone who needs treatment but is worried about the legitimacy of FixhepC. As those of us that are now cured know it may seem too good to be true but it really is good and true.

I also had Hep C for 30+ years and had children that may have been infected. One son is carrying antibodies suggesting that he was exposed to the virus but his body managed to clear it. Ahh the guilt of a mother!

Good to hear that things are returning to normal for you - it takes a while for the drugs to get out of your system. That fatigue and brain fog is a killer. Sometimes it's hard to believe how bad I felt and how much the virus affected my life but now that it's gone I think it's really important to be thankful and look forward.

It's great that you had some good support around you. Take it easy and there's nothing wrong with a bit of Netflix every now and again.

Coral #flower
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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REDEMPTION 4 - Epclusa - 12 week course - Experience 2 years 2 months ago #25338

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Hi sixtieschild,

Thanks for sharing your story. It really highlights the caring Dr. Freeman has for his patients, and the amazing opportunity to access different meds this side affords. What a great opportunity for Hep C patients. Good luck with your treatment!

Viva Fix HepC :cheer: :+1:
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs, VL UND, AST 27, ALT 20
EOT labs, VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24, VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
Last Edit: 2 years 2 months ago by Greedfighter.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 1 year 9 months ago #25926

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hi. Yes I took epclusa and my viral load became undetectable within 4 weeks. It's 4 months since I began treatment and my labs are still undetectable.

The side effects were difficult but worth it. Worst side effects were fatigue and confusion. I had fatigue almost all day long, and I would pass out mid sentence sometimes and if I sat for more than 10 minutes. The confusion would come and go. I would forget things like which day of the week it was. Having long conversations was difficult. It was difficult for my thoughts to continue that long.

Other side effects. In the first month I had nausea. I had dizziness throughout treatment. So dizzy I had to lay on the couch and I couldn't lift my head for about half hour. I also got a blister rash that would come and go. Occasional weakness too.

Again, all of these side effects were worth the result of the treatment. I did not drive during the 3 months due to my extreme fatigue and confusion and I regularly had friends and family help with my kids and help take care of me.

Good luck it has a really high cure rate so stick it out to the end. Also, I was told my side effects were more intense than some experience.
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REDEMPTION 4 - Epclusa - 12 week course - Experience 1 year 9 months ago #25927

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Also, I forgot to say that after 4 weeks my liver and kidney functions skyrocketed from before treatment. Everything in my blood test was completely normal after just 4 weeks. So the hep c was really effecting me, and once it was gone boom my body was doing great. I did show very small damage to my liver before treatment, not enough to be cirrhosis. So it was amazing that my liver began working so great in just 4 weeks.
Good luck to everyone. This medicine is just amazing. It brings tears to my eyes to know that I have been blessed with a cure and that others can too.
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