I don't want to get into a fight with you, Sir. So if that's what happened, OK. I trust he is the subject of further study as his situation would appear to be unique.
At the same time, as some people here find Tx and waiting for SVR very stressful, nor do I think it is helpful to add to that by having them think their genotype may mutate into another genotype when the literature says it is not possible.
, first para of page2:
A blood test is required for the genotype test. Gener- ally, a quasispecies test is only performed for research purposes. HCV genotype testing is only done once since the genotype does not change unless someone is re-infected with a different genotype.
about 3/4 of the way down under "Is it necessary to do viral geno typing when managing a person with chronic hepatitis c?":
Once the genotype is identified, it need not be tested again; genotypes do not change during the course of infection.
As far as the accuracy of genotype testing, I haven't been able to find anything. I know PCR tests can produce false positives/negatives and may be repeated and there is a lot of literature about that. But as I couldn't find anything about genotype testing efficacy and as I can't recall reading of a case where they got it wrong, I can only assume there is a high level of accuracy.
Thurl, I'm sorry if you failed to pick up the humour in my comment. I should have added a smiley. I just think that the world is not black and white. There is a lot of gray. There are good reasons for Prof Gane having links to Gilead. It does not automatically follow that he is the devil incarnate. In saying that some of the generics may not be bioequivalent, he is simply stating a fact it seems to me. This does not mean they aren't bioequivalent or, even if they aren't, they won't work. Nor does it follow that he is arguing people should not take them. Indeed, other parts of the interview indicate otherwise.
I have always factored in the possibility of failure and, from the start, determined to keep hammering away from it. After all, with my level of fibrosis what else can I do? But in the meantime, I'm content that I'm giving it my best shot. I'm buoyed by the fact I still had enough get up and go left in me to hunt down the generics. And I'm proud I had the courage to take what I consider to be a well calculated leap of faith but a leap of faith nevertheless.
And I think everybody else is best off focusing on those things too and not the what ifs. If others feel differently, so be it. But personally, beyond having already decided to have another go in the case of relapse, I see no point worrying about crossing bridges that the science says I will probably never need to cross.