TOPIC:

On the issue of "genotype change", it was postulated in another thread that someone could be co-infected with multiple genotypes but the test may only detect one. Possibly if G4 was detected and cleared, a co-infection with G3 could have been present and not cleared but detected in subsequent test. Only a theory but sounds more likely than genotype morphism.

I agree with LG......since reading about Professor Gane's comments (not just on this thread) I have been worried. Up until I read the thread I wasn't. I have no doubt that the meds were tested properly before I received them but the niggling doubt that I may relapse has now been planted. I I think I will stop reading for a few weeks until I get my first lot of post treatment results back (3 weeks' time.

And this is why I asked for a medical opinion and clearly we have one
Lets just relax
Relapsers from peg/inf like myself already suffer interferon induced anxiety (well a few do) we may have been on the phone alone in the night to lifeline while in that dark hole (I was)
I was like Lynne, alarms and red flags waving when I read this thread.
I agree lets just realise how early on we are as a tx cohort anyway, get on with staying positive of mind and all agree that there could be some data errors, some affiliates of big pharma, some speculation but that our common goal is to achieve a stress free future
It's been a fascinating read since I first posted here and a hot topic
Cool down time? Phew!
Sending a splash of cool water
Ariel xxx

It is worrying for everyone on Twinwir or Chinese API. If you already finished the treatment, there is nothing you can do now, apart from keep calm and hope for the best. Staying away from the forum will help as well.

For some of us, who still on tx, is anyone planning to add licensed Indian sof/led for at least 4 weeks, to make sure that the virus hit hard? In some cases we probably just need to replace Twinwir with licensed for the remainder of the treatment.

Hi Folks,

It seems like a lot of people are getting worried about that remark from Prof Gane about the *possibility* of relapsing with certain generics.

Dr James has verified by NMR that all the generics sourced by the FixHepC Buyers Club and that the generics manufactured by the companies recommended on the FixHepC web Forum are chemically equivalent to the patented molecules:

fixhepc.com/blog/item/16-testing-provisions-patient-safety.html

This means that apart from a few minor (and probably irrelevant) arguments about solubility and kinetics, Dr James has done everything humanly possible to show the generics that we all are taking may be assumed to be bio-equivalent to the patented molecules.

As several other people on this thread have already pointed out (mgalbrai, Price, Sirchinenge, GAJ, ...), you just need to look at our forum signatures to see that the FixHepC generics are working extremely well. This is overwhelming evidence that there is no difference between the FixHepC generics and the patented molecules. The NMR spectra say we are taking the correct molecules. All the results posted so far say we are taking the correct molecules. So do not worry, do not fret! Molecules do not know about nationality or packaging. All the evidence so far says that the molecules made in China, India, and Bangladesh are the same molecules as the molecules made for Gilead in Ireland.

Here are some results posted previously by Dr James from previous trials using molecules made in the USA or Europe:

fixhepc.com/forum/questions-and-answers/...ol.html?start=6#9804

Probably a lawyer would say that NMR doesn't prove bio-equivalence... The final proof will be the results from the REDEMPTION trials. I am sure that once the results are in they will show comparable or better statistics. Probably better because REDEMPTION will be the biggest trial ever.

Personally, I am already absolutely convinced that the generics I have been on are bio-equivalent. But I am a chemist, not a lawyer. REDEMPTION will provide the ultimate proof.

So for what its worth, my advice about the risk of relapse is this - DON'T WORRY, IT WILL PROBABLY NEVER HAPPEN.

But even if the worst does happen, it will be just bad luck and nothing to do with which little country (joke) you got your treatment from.

Yours,

Oor Wullie

(Expert in Catapults and Chemistry)

Worry in one hand,
Take a crap in the other.
See which one fills up the fastest.
We have all heard that and probably know that worry is an absolutely useless emotion. Acting out of concern to change an outcome or perceived injustice is not the same as worry.
Most of the issues I am seeing discussed here have been addressed by Dr. Freeman in an earlier post. The nail has been hammered, set. the hole filled, sanded and painted over.
Either you believe in Dr. Freeman, who has no problem with Mesochem, or you don't.
He is the only reason I am here.
I believe in his judgement.
Mike

Hi ,
I am on TWINVIR and of course that I am worried.
I am worried about slow response, being UND in between week 8 and 9. Worried about viral load at EOT.
Worried about SVR at 4/12/24 weeks after EOT.
But I am not worried about the quality of sof/led of Incepta.
Because it was tested by specialists in Australia and because many people here and on other forums reached UND after 2/4/6/8/10 weeks.
I am not worried because I trust dr. James.
I am not worried because I will never afford the original licensed Harvoni 80000 USD or 40 000 Euro in France.
So I took my chance with generics, I bought Twinvir directly from Incepta. It was me and two other companions fighting for a life without HCV. In my country I am not sick enough to be treated with IFN free medication! I have to wait until F4, maybe F3.
Only time will prove if the desired SVR12 will be reached by each of us.
Only UND for all of us!

Worry over one's health is normal.
Beating a dead dog to death is not.
M

Man, everyone needs to take a collective deep breath:)

On occasion you need to have faith that this is all going to work out this is one of those moments.

Other wise you're ruining what should be very happy time.

Exactly Sir.
This should be a very happy time. I am virus free for the first time in my adult life. I am elated. The main thing is, right now, the virus is not destroying my liver.
I plan to be able to say that every day from now on.
If a problems arises, I will deal with it.
M

Yeah, seconded.

Please can someone change the title of this thread to "Prof Gane's remarks: implications for total recovery", move it to the "Don't Worry" archive, and then close it from further posts?

Whether we relapse or not is actually irrelevant. We still must do all we can at a specific time and that time is now for most of us. You can't just sit and wait forever for 'something better to come along'. It has. We did. It's good. Thank you. (bowing........bowing again)

splitdog wrote: Whether we relapse or not is actually irrelevant. We still must do all we can at a specific time and that time is now for most of us. You can't just sit and wait forever for 'something better to come along'. It has. We did. It's good. Thank you. (bowing........bowing again)

Makes sense to me.

We have had it drilled into our heads that we wait.......

I will now happily wait for anything; the difference is my LFT's are somewhat normal and any Hep C virus is hard to find.

What Prof Gane says is undoubtedly relevant and needs consideration.

Heard the concerns (always is about generics) before though, and made a decision that is applicable to me.

I am not posting this just to talk myself into believing everything will be okay. I just keep looking at the signatures and find that more relevant to me.


yours


J.

What we all are and have been participating in all along is a HUGE clinical trial. The results of which will have far reaching impacts on the availability of affordable HCV medications to all that need them. REDEMPTION is just a name for it.
This is the beginning of the end for HCV.
Now we will have some war stories to tell in our later years.....
Because we can have some later years in which to tell them.
M

Yup exactly Mike
I threw a big cool bucket of water out yestey here didn't it splash far enough
Yes we are the early cohort
Let's be happy
I'm sure a lot of these remarks by Gane are trying to be constructive and can be interpreted a thousand ways but we are safe with our choices and in FANTASTIC care here with James and team
Here is some more soothing cool water