TOPIC:

New-Onset Diabetes Mellitus With Exposure to Ledipasvir and Sofosbuvir.

hic.sagepub.com/content/3/4/2324709615623300.full

Anyone on the forum have measured the glucose during treatment?

Hi Enkel, No, but have always said, that while on tx, it makes sense to me to keep an eye on general observations, the more the better.

This report was only 2 patients from what I understand? one co-infected with HIV and the other obese,
Is there an easy test for Diabetes / Pre diabetes, or is it blood test only?

The old therapy induces diabetes too

www.ncbi.nlm.nih.gov/pmc/articles/PMC3161293/

If you look at what the CDC has to say about it

www.cdc.gov/diabetes/statistics/incidence/fig3.htm

You will note that people in the 45-65 age range have an annual incidence of 12 per thousand. That is 3 per thousand per 3 months.

So all other things being equal 1:300 patients aged 45-65 who are on ANY 3 month treatment will develop diabetes.

This is not to say insulin resistance and HCV are not related, simply that STUFF, as in all sorts of stuff happens to patients on and off treatment.

mYes, was about to say, Diabetes is quite common with those with HCV and those over 50.

Keep a healthy diet, have a check here & there, get rid of HepC !

Having HCV substantially increase your risk of developing Diabetes...

www.ncbi.nlm.nih.gov/pmc/articles/PMC2669937/#!po=1.08696

Among those at high risk for T2D, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop T2D (relative hazard, 11.58; 95% CI: 1.39-96.6)

London girl:

According to the American Diabetes Association, a fasting blood sugar above 100 gives you a diagnosis of pre diabetes, which means you're insulin resistant.

A HOMA obtained with a formula that uses blood sugar and insulin levels can also tell you if you're insulin resistant.

P.

The study says the ION-3 clinical trial showed that in those who received ledipasvir/sofosbuvir for 12 weeks, the hyperglycemia rates were.....
grade 1: serum glucose > up to 160 mg/dL......33.3%
grade 2: >160-250 mg/dL....11.6%
grade 3: >250-500 mg/dL .....2.3%
grade 4: >500 mg/dL
Those who received the medication for 8 weeks had hyperglycemia at the following rates: 21.4% (grade 1), 7.9% (grade 2), and 1.4% (grade 3).
All patients with Grade 3 or 4 increased serum glucose had either a medical history of diabetes or glucose intolerance (HbA1c > 6.0%) at screening

That's worse than interferon.

P

Price,

Can you post the link?

Price you should add this:

All patients with Grade 3 or 4 increased serum glucose had either a medical history of diabetes or glucose intolerance (HbA1c > 6.0%) at screening

I have type II diabetes and my sugars have been extra low during tx. Suffering more from hypo than hyperglycemia. I take no meds for the diabetes. I just control it with diet and exercise. I check my bloods a fair bit.
I just figured that the diabetes was being at least partially caused by my liver, not my pancreas, and the low numbers were a result of tx. Hmmmm.

Hmmm
So, 'serum glucose' is what it looks like on the blood test?
I don't think I've ever had one of those tests.
May be worth keeping an eye on the GP will run a test. Why not?

I have read that some patients were pre-diabetes before treating and then after SVR it went away.
I guess we just have to do careful watching for a few things, an unwell liver can cause a lot of problems.

Enkel said "All patients with Grade 3 or 4 increased serum glucose had either a medical history of diabetes or glucose intolerance (HbA1c > 6.0%) at screenin" - Ahhh thanks Enkel, thought those figures rather high!

That's because HCV causes diabetes.

I preached about insulin resistance for years,
www.projectsinknowledge.com/cc3/index2.cfm?id=243

so ban me now or I'll drive you crazy talking about IR.
I'm thinking the Zolpidem on your cheat sheet can cause hyperglycemia.

P.

It's a big can of worms. You won't be able to take meds that increase blood sugar and there are many that do. Plus having high blood sugar predisposes you to getting infections.

And nobody will like me again because I'll tell them not to eat chocolate and ice cream

P.