TOPIC:

Hi there,
I have been bravely putting up with my gastritis/reflux throughout tx with well under the minimum that gilead says you can take of PPI's and antacids. Have 9 days left of tx. Anybody know if I can start using these meds again immediately after tx, or if i should wait a while. Any help would be greatly appreciated,
Ken

The advice was to use them 8 hours before you took sob/led I did four extra weeks
of sob/led and took them every other day no way Id be able to live with out them.

Id start back now and make sure you take the anti acids 4 hours before the Harvoni.

Hi Ken,

The recommendations on PPIs and antacids is because Led requires high acidity to be absorbed. So if waiting until EOT to recommence then you should be able to use them again within a few hours of your last pill as it will have been absorbed by then. Extreme caution would be to wait until the following day.

Thanks Gaj and Sirchinenge,
Just wanted to make sure because all this talk of 1/2 lives of the meds and such is kinda over my head and didn't know if it needs to be taken in to consideration at EOT...

I'm having nights of indigestion on sof/led too
Bring on EOT only a month to go
I don't usually have gastric reflux and I am soooo acidy
Ty for this post cheers Ariel x

Hi,
The ledipasvir needs an acidic environment to breakdown and be absorbed properly. So, acid reducers 4 hours before or after dosing. According to Harvoni packaging info, omeprazole (Prilosec) should be avoided, famotodine (Pepcid) is not mentioned.
Makes sense, since Prilosec takes a while to begin to take effect.
I was taking both and another custom compounded med for my horrible dyspepsia. It gradually got better after a year of no alcohol and animal fats. I love bacon. It was guaranteed to give me violent reflux, bloating, nausea and belching this tasteless white foam. It got so bad, I would eat food one day, knowing I would be up all night with dry heaves and reflux you could choke on. Then totally fast the next day and get some sleep. I had two endoscopies to determine the cause. Gastritis. I was a regular drinker with a cast iron stomach until I turned 60. Then, BOOM! Then best relief was to walk. Walk until the food and foam settled. I walked a thousand miles that horrible year, mostly at 2 or 3 in the morning. Good news is no high blood pressure and a resting HR of 50bpm.
So, I haven't had any problems at all, during or after tx. I do have a beer along. One very good, locally made, very tasty, very potent bottle of Farmhouse Ale.
I don't think I will ever be able to eat bacon again. The thought of driving the porcelain bus pops up every time I see or smell it.
Oh well, I'm sure the pigs are happier!
Mike

Ken, too be clear as you appear to have stopped taking the anti acid medication whilst
on DAA i think you should start taking them now I think if you take them 4/8 hours before the
Sob/led you're good to go.

Hey Mike,
That is strange about the omeprazole being avoided. On the gilead pdf for harvoni they mentioned that you can take 20 mg a or less a day with the meds in fasting condition. I have done just that for about 20 days of tx. I hope i didnt screw up!

That was my PCP who said that. I would go with the Harvoni recommendation.
He simply said these DAAs were so new nobody really knew exactly what to do safely.
His advice: Don't take anything you don't have to while on tx.

Ken hi, do you find nights are the worst?
I'm having porridge in the morning around 5.30am which is when I really cannot be bothered with it anymore and it helps settle things down. I'm mixing the oats with milk not water and adding a few seeds and sultanas. Only half a cup of coffee waah
Not long to go anyway good luck for your EOT

Only half a cup of coffee waah

I'm off the coffee in the morning now - double whah whah !

I feel your pain hun, my GP said no but Dr J said go
So I split the difference haha!
I am up so much in the night I would possibly commit a grizzly crime involving a coffee plunger without my half a cup xx

Hi there Ariel,
Your gp and Dr.J said no and go to what exactly? I have it worst in the day. I just don't feel like eating and then to my surprise a lot of the time it does actually make me feel somehat better.,Today is.one of the days i am fighting through with no reflux meds so I am all grumbly in my tumbly

Hi Ken I was just meaning coffee as LG and I were chatting over
No not taking antacids never have before
Yes hideous gastric acidy gut on sof/led here
The porridge is good
Ariel x

I would possibly commit a grizzly crime involving a coffee plunger without my half a cup

I hear you sista!