Price wrote: As Dr Ponzetto said sof IS a 5fluoro uracil-
No, he did not
! He stated "since it is a 5Fluoro-Uracyl -like compound"
"Is" and "like" are not interchangeable words particularly in this sort of discussion.
"Sofosbuvir is a phosphoramidate prodrug that is metabolized in the liver to β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate."
I just want to make sure that readers realise that while the above quote and citation are fine they are not attributable to A. Ponzetto.
Knowing exactly what you're taking can help prevent, identify and treat side effects. For example, the literature says that skin redness can be helped by Pyridoxine (Vitamin B6). Obviously, everything should be checked with your doctor.
Very true but "knowing exactly" is the important point and Sofosbuvir is not
exactly 5Flouro-uracil so you should not be extrapolating treatment from one to the other. Your advice about checking with a doctor is sound.
I would also like to point out that in your original citation A. Ponzetto goes on to comment about the toxic excretions of bacteria (h.pylori) that at least 50% of the human population carries in our digestive systems and also about the levels of chemotherapy type molecules in the food and water most of us eat and drink. My reading of that is that he is not trying to scare us but to point out that many items we ingest carry some very, very small element of risk but many benefits and Sofosbuvir fits in that category.
We know that Sofosbuvir may
have some side effects and very occasionally a patient may
have more serious adverse events, that has been well documented. However, it does not mean that every event that occurs while on treatment relates to that treatment. In JamesF's instance he has a reddening of the skin, it may be from Sofosbuvir but then again millions of people worldwide get rashes everyday without taking Sofosbuvir. He has wisely sought medical advice and both his specialist and Dr James have suggested monitoring as appropriate at this point, I'll back medical opinion.