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TOPIC: Missed dose - worried - should I take extra?

Missed dose - worried - should I take extra? 6 years 4 months ago #8840

  • Phoenix
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Hi, was 2 and a half hours late with my dose today. How bad is that? How much more depleted would the medication have gotten in my body in that time? Should I take an extra dose today to try and nuke any viruses that were encouraged to develop resistance by the holiday I gave them? :huh:
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Missed dose - worried - should I take extra? 6 years 4 months ago #8841

  • Phoenix
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I should add that I'm on day 20 of sof & dac.
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Missed dose - worried - should I take extra? 6 years 4 months ago #8843

  • Joy
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Can't find the post now but recall Dr James saying don't be alarmed if you're a bit off schedule. I wouldn't take an extra dose without speaking to the doc first.

I took mine just before bed, which ranged from 10pm - midnite.
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.
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Missed dose - worried - should I take extra? 6 years 4 months ago #8844

  • splitdog
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2 1/2 hours I would think is nothing. No worries......
This email address is being protected from spambots. You need JavaScript enabled to view it.

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Missed dose - worried - should I take extra? 6 years 4 months ago #8848

  • CC2B
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You should be fine 2.5hrs isn't too bad. I do remember reading something about it on here. Someone will find it or maybe Dr Freeman will get back to you. Do not take extra dose! I do remember that part of it.
GT2b diagnosed 10/2015
since: unknown
11/20/15 VL= 214,070
12/4/15 ALT=18 AST= 24
1/16/16 started sof/dac
2/13/16 @4wks VL=UND ALT=13 AST=22
3/12/16 @8wks VL=UND ALT=10 AST=18
4/9/16 EOT VL=UND ALT=11 AST=19
9/23/16 SVR24 ALT=11 AST=22
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Missed dose - worried - should I take extra? 6 years 4 months ago #8849

  • Joy
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NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.
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Missed dose - worried - should I take extra? 6 years 4 months ago #8851

  • Phoenix
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Thanks very much for that Joy - it's immensely reassuring! :)
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Missed dose - worried - should I take extra? 6 years 4 months ago #8858

  • Paul-Jarman-facebook
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Sometimes my doses have been off by 6 hrs due to shift work then I just take them when I can.

Just to clarify for most of the time it's regular 24 hr periods but I seem to be about 3 few days in front :)
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
Last Edit: 6 years 4 months ago by Paul-Jarman-facebook.
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Missed dose - worried - should I take extra? 6 years 4 months ago #8861

  • CJ
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My J had to miss one whole day one time when he had a gastro bug :ohmy:
But that was OK, Dr James said.

So don't worry :)
x
J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results....pending....
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
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Missed dose - worried - should I take extra? 6 years 3 months ago #9328

  • DrJames
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Hello Phoenix,

It is not even a slight worry. Only very low dose things like the mini pill require taking within a 3 hour daily window to be effective.

In the PROTON study people taking 200 mg of Sofosbuvir+Riba had a 90% SVR rate, versus a 91% rate for 400 mg. You are not taking mini-sofosbuvir.
YMMV
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Missed dose - worried - should I take extra? 6 years 3 months ago #11501

  • Phoenix
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Thanks all. Very reassured! :)

Sorry no reply for a while - been trying to just take the pills, then avoid all thoughts of disease and just live...
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