emo Ledipasvir or Daclatasvir

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6 years 8 months ago #607

API prices will fall over time, so the meds should be cheaper. Mesochem price is for very small quantity in API market terms. Usual orders are for kilos, not grams. Bulk purchases are cheaper.

We are testing Twinvir in the lab now and will post about it as soon as results are to hand.


YMMV
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6 years 8 months ago #612

How about side effect profiles Ledipasvir vs Daclatasvir? Which one is most likely to have minimum effects so that I can work through the treatment? :whistle:

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6 years 8 months ago #614

Most people's experience of treatment is 3 days of 'pre-flu' like illness - not fully well but hard to put your finger on it.

This is followed by feeling better than you have for years with more energy and a clearing of brain fog.

Some patients have headaches, particularly at the start. My first patient had severe headaches the whole time, but has now finished treatment and is VL 0.

Insomnia is also pretty common.

The DAAs are not like interferon - you will almost certainly feel better on treatment than you do now after the first week.


YMMV
Last Edit: 6 years 8 months ago by DrJames.

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6 years 8 months ago #706

Is there a general picture appearing re sides Harvoni v Sofo/DAC ?
Still deciding here , or trying to !
Any advise welcome. Thanks


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #712

If you are young, I would say on the right side of 50, don't have problems with the blood pressure, cirrhosis, autoimmune and other complications , there is a good chance you would not have any side effects at all!


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6 years 8 months ago #713

Wrong side of 50 & suffering a variety of ailments, think all HepC related. Blood pressure Ok when it's rarely checked. This is why I really don't want Interferon at all, My immune system is already fighting & causing problems.


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #714

Who is suggesting you take interferon? Surely the NHS offers Haveron as a stand alone treatment.


Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

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6 years 8 months ago #715

The final appraisal from NICE for NHS England is due this coming November, then it will probably take 3 months from that date. Then it will be up to the NHS commissioners and local hospitals. There will be waiting lists, so I believe the triple sofo/Interf/Riba may well be offered to many who don't wish to wait. Some have been told waiting list is 2 years already. I guess it will depend on your post code. I know someone with cirrhosis who has not yet started treatment, all those patients are supposed to have started treatment by now. Unbelievably, there are people being offered the old triple here in England! As for me, I was mainly talking about my initial feeling when first diagnosed and in response to Nadia's comment above. Lasts bloods showed 'strong auto-immune response' - I need to do what I have to do if treatment isn't forthcoming and have other health issues I believe are caused by the virus., even then, if all goes well NHS England will only offer 8 weeks Harvoni. I guess the logic is many will clear and it'll be cheaper to re-treat the 6% or so that may fail. We are waiting to see what NICE say, but in reality, it will be down to individual hospital budgets and where you are on the list. So we have to wait for NICE then see our consultants for adise in our area, I don't think there will be identical treatment options in every region. Hope I'm wrong, but that's what I've deducted from a variety of articles, videos and professional opinions, you know? Things are different in Scotland and Wales. Scotland have officially got rid of Interferon treatment for GT1s. Go Scotland !


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #716

I don't want to speak to soon but I'm already starting to notice improvements in my digestive system and overall health .I Sleep well , eat well, no headaches , no fatigues, no mood swings. I'm so glad I didn't go interferon route.


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6 years 8 months ago #717

Looks like I've lost your private message again. They keep disappearing.


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Last Edit: 6 years 8 months ago by Nadia.
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6 years 8 months ago #718

Good to hear Nadia, long may it continue that well.

What I am trying to understand I guess, is are there any differences showing between the Harvoni and the Sofo/DAC treatments. Are there any over 50 GT1s with aches and pains pre treatment on here who have taken Harvoni? Or are there any reports on either treatments to compare? Etc I am doing my homework :)

If I need to get a prescription, I have to decide what for.


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #719

Nadia, I wonder if when we are typing a post, it doesn't work?


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #720

It is there in the background but I can't view it.
With regard to side effects. I think most of them are actually from Sof and Riba. There's no much difference between Dac and Led. Both of them work really well with GT1. If you are happy to take API, go for a Dac option. If you are not too sure, wait for the official generics.


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6 years 8 months ago #721

When are the 'official' generics due. confused :huh:


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 8 months ago #722

Hepcinat LP (Ledipasvir) Has been registered back in July. I think they are pushing to skip the Clinical trials and start selling ASAP. So nobody knows yet.
I think this chat option is not very good for the androids. I will try to log in from my laptop.


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