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Ledipasvir or Daclatasvir 7 years 1 month ago #1404

Is there any evidence to suggest ledispasvir combined with sof and dac may increase svr numbers ?
Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib

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Ledipasvir or Daclatasvir 7 years 1 month ago #1426

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Hi Paul

I've had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven't seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don't know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said 'it aint me'. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Ledipasvir or Daclatasvir 7 years 1 month ago #1428

Can't see the logic in using two NS5a inhibitors. Dac is the stronger of the two.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Ledipasvir or Daclatasvir 7 years 1 month ago #1430

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Yep that's right daclatasvir has a 3.5 kill log whilst ledipasvir has 3.0. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Ledipasvir or Daclatasvir 7 years 1 month ago #1431

emilio wrote: Hi Paul

I've had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven't seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don't know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said 'it aint me'. Em


It's kind of like the nuclear option as far as I can see if i'm not SVR -0 @ 4 weeks or close to it I would add Rib as well. I don't want to be doing this again. I was a non responder on a Dac trial in 2011 with Inf and Rib, Crash or crash through someone also said :)
Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib

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