TOPIC:

Ledipasvir or Daclatasvir 8 years 6 months ago #1404

Sir-Paul-Paul-MJ-twitter Offline New Member Posts: 16 Thank you received: 11	Is there any evidence to suggest ledispasvir combined with sof and dac may increase svr numbers ? Gen 3a Started Sof Dac 16/10/15 V/L 20 Mill + Hep C pos approx. 27 yrs Non responder 2011 BMS (dac) Peg Rib

Ledipasvir or Daclatasvir 8 years 6 months ago #1426

emilio
Offline
Moderator
In the field of opportunity its ploughing time
Posts: 382
Karma: 8
Thank you received: 475

Hi Paul

I've had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven't seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don't know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said 'it aint me'. Em

Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

Ledipasvir or Daclatasvir 8 years 6 months ago #1428

Johnboy Offline Premium Member Posts: 91 Karma: 1 Thank you received: 78	Can't see the logic in using two NS5a inhibitors. Dac is the stronger of the two. G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015 The following user(s) said Thank You: Sir-Paul-Paul-MJ-twitter

Ledipasvir or Daclatasvir 8 years 6 months ago #1430

emilio Offline Moderator In the field of opportunity its ploughing time Posts: 382 Karma: 8 Thank you received: 475	Yep that's right daclatasvir has a 3.5 kill log whilst ledipasvir has 3.0. Em Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

Ledipasvir or Daclatasvir 8 years 6 months ago #1431

Sir-Paul-Paul-MJ-twitter
Offline
New Member
Posts: 16
Thank you received: 11

emilio wrote: Hi Paul

I've had this discussion with others including James and one would assume so, however, there has been no research on this whatsover, well I haven't seen it. Both are NS5As so if we go with the theory of adding additional weapons then yes, however, will they counteract both or either?? We don't know? What about using Dac for the first 6 weeks and then finishing with Led?? Someone will eventually try combo, but as Dylan said 'it aint me'. Em

It's kind of like the nuclear option as far as I can see if i'm not SVR -0 @ 4 weeks or close to it I would add Rib as well. I don't want to be doing this again. I was a non responder on a Dac trial in 2011 with Inf and Rib, Crash or crash through someone also said