emo Hard to treat Gt3 - Another stage of the journey

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5 years 11 months ago #19435

Hi all,

While obviously a bit disappointed I'm not disheartened thanks to all my wonderful friends here who help keep me strong and focused on the future. As others have said Gt3 can be more difficult to cure particularly if you have cirrhosis but with the new medications steadily being advanced and targeted at this problem there will be other opportunities to clear this horrible virus, hopefully very soon. :)


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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5 years 11 months ago #19439

Hi Gaj

I’m sorry to read that the virus is detected again. The GT3a virus seems to have mutated into the boomerang genotype, as it keeps on coming back. However, SOF + VEL looks like a promising weapon to eliminate it. The most problematic NS5A RAV for this combo appears to be the Y93H variant, so hopefully your baseline tests will not find it.

Stay positive and patient. I have no doubt that you’ll eventually beat it with persistence and determination.





Best Wishes
GT2

Attachments:

1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
Last Edit: 5 years 11 months ago by GT2.
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5 years 11 months ago #19454

So sorry to hear your news, Gaj, but you'll get there in the end.

All my best wishes,

R


G3a. Probably infected 40 years ago.
Diagnosed July 2015
7/7/2015: ALP 69, ALT 209, WBC 5.8, VL 40,000. Fibroscan 9.5 Kpa.
Commenced treatment Sof/Dac (Natco Pharma) 24 wks in Feb 16
VL UND @ 4 wks, 12 wks

EOT 6/7/16
SVR 12
SVR 24

PHEW! Thank you so much Dr James, Monkmeds and all at Fixhepc
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5 years 11 months ago #19468

Hi, Gaj, sorry to hear this... Probably, you had relatively strong NS5A resistance before starting of sof-dac therapy, due to previous exposition to dac during first peg-dac-rib therapy... Such resistance may cause relapse. I dont know about retreatment data with velpatasvir after 24 weeks of dac/led therapy. If you don't have resistance to sofosbuvir, possibly peg-sof-rib may be an another option. Probably it is better to perform mutation testing before next therapy attempt.

P.S. Is lab error possible with "false positive" result?


Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
Last Edit: 5 years 11 months ago by Serg.
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5 years 11 months ago #19471

Really sorry to hear this GAJ :(
Hopefully the blood work you gave them can help you determine what ravs you have so that you can figure out what would be your next tx option is. Hopefully some of these new drugs coming out soon can eradicate these buggers.
I hope you get some answers to what direction your next move is very soon.
#love


GT2b diagnosed 10/2015
since: unknown
11/20/15 VL= 214,070
12/4/15 ALT=18 AST= 24
1/16/16 started sof/dac
2/13/16 @4wks VL=UND ALT=13 AST=22
3/12/16 @8wks VL=UND ALT=10 AST=18
4/9/16 EOT VL=UND ALT=11 AST=19
9/23/16 SVR24 ALT=11 AST=22
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5 years 11 months ago #19479

Hi Gaj just logged on , havent been in touch with the forum for a while. Cant believe the bad news, sorry the jouney continues for you. You have been and continue to be such a wise and gentle influence on the forum , Ive appreciated the help and information you've given . Your one of the first in the core group which set such a high standard in this forum, and well done forbeing so stylish in the face of adversity. I find sometimes theres nothing else left to do but, go fishing, worry can wait. Best Wishes Jill


Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
24weeks mesochem sof/led as unsure of fibrosis status.
currently UND. No bad side effects
Have svr12 ... waiting for svr 24
I now have SVR 36 weeks.
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5 years 11 months ago #19506

Hi Gaj, so sorry about your blood work. The newer drugs sound promising. Wishing you the best with the next therapy. Thank you for all the support you have given to others. :whistle: #flower


HCV since 35-40yrs., GT 1a , Dx 2004; VL 4-5 mil, F2-3
Tx sof/led started 3/4/16
4wks VL <15
9 weeks VL UND, ; Alt-15,Ast-13
16 weeks VL UND Alt-20, Ast-22;
EOT 24 wks UND
SVR 4 UND
SVR 12 UND, Alt.15, Ast. 17
SVR 24 UND
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5 years 11 months ago #19521

Gaj, bummer news. But with the Sof/Vel I'm hoping us 3's that rebound have a chance. Jim


This email address is being protected from spambots. You need JavaScript enabled to view it.

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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5 years 11 months ago #19544

Thanks Jim, Sof/Vel certainly looks promising based on the clinical trial results for Gt3s like us. :)


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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5 years 11 months ago #19545

ah Gaj,
What a sad thing to hear, I've been offline for quite a while, just logged on & saw this, really sorry .

I know you're so strong, & don't let things faze you much, you were always there for me & J when he was treating, thank you so much for that.
Keep up that strong attitude, you'll beat this.

The different oral drugs being developed now , makes that hope pretty real now :)

I'm going to log in more often to see how you go.
Good luck my friend.

Love Cindi x


J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results....pending....
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
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5 years 11 months ago #19552

Gaj, sorry to hear of the return. You have been such a positive influence here, it's not fair that you need to keep on fighting. Best wishes for a final solution.
@splitdog - crossed fingers for you too, hope the next one is the charm.


M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
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5 years 11 months ago #19554

Gaj, I've been off line for a bit..recently logged in...and was really surprised, albeit very saddened to read the wretched Detected word is back for you & Splitdog...

As you can see I'm also G3. I'm almost too scared to have follow up bloods done..I've read a little bit and can see G3 is a tough one to shift...I'm wondering if all G3s fail Sof/Dac treatment..

I'm really sorry if I'm sounding self indulgent or sound in any way insensitive or selfish regarding your confirmed status...


Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
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5 years 11 months ago #19555

Hit The Road Jack wrote:

....I'm wondering if all G3s fail Sof/Dac treatment.

No, on the contrary the overwhelming majority are successful in achieving SVR. While G3 is often a bit more difficult to treat than the other genotypes, Sof/Dac has been the most effective treatment available for this genotype so far.

The main problems with us G3s seem to be related to cirrhosis, previous Tx, VL and length of Tx. I score very poorly on the first three so went into 24 week Tx knowing I only had a 80% likelihood of success based on previous studies. While I didn't achieve SVR my overall health has improved in leaps and bounds putting me in a good position to do so next time.

In your case with F0, naive and low VL you had a 96-97% chance based on trial data, then you extended Tx to 16 weeks which helps even more. I understand how nervous you must feel approaching SVR but you have done everything possible and are in an excellent position to succeed. I look forward to cheering when you cross the line! :cheer:


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 11 months ago by Gaj. Reason: #*+%^~! Autospell
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5 years 11 months ago #19556

Gaj as a fairly new member here I have read many journeys, all are done with inspiration, determination and with a positive mindset that only those whom have this disease truly know. I applaud your journey as you will not let getting kicked off the bucking bronco stop you from your determined goal, SVR. Yes it is a frign bad deal, to say the least, when your SVR went south but from reading your posts you will not be denied. The Sof/Vel treatment looks extremely good in trials, you are here with the people who know you and support you and you have the best team with Dr James, MonkMed and GP2U..... you'll make SVR. As one me,bet told me the other day, something I have not heard in a long long time, "we've got your back"! You will succeed because we won't let you leave here without SVR!
In good health my friend.


Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
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5 years 11 months ago #19558

Gaj, thank you for being so selfless and reassuring with your response...
Id like to take this op to thank you for alway being so giving re: this forum...& I have little doubt, once you kick this virus, there won't be a dry eye in the house.
You take care :)


Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
Last Edit: 5 years 11 months ago by Hit The Road Jack.
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