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Hi JamesF,
Here’s a link to Dr James’ comments. https://fixhepc.com/forum/questions-and-answers/622-missed-dose-worried-should-i-take-extra.html#9328
As the others say, it is a good idea to take at the same time each day so it is a habit. I took mine when I got up and used a 7 day pill box so I didn’t lose track. That always sat on my place at the dining table where my cereal bowl needed to go so I had to move it to eat meals which made it difficult to forget to take my dose. As beaches says many set their phone alarm as a reminder.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi James,
I took mine at night as I guess initially I wanted to give the medication a clear run and I wasn’t sure what the side effects would be (minimal as it turned out). There were a couple of times when I realised I’d forgotten just when I was drifting off to sleep and had to get out of bed to take the tablets. I missed twice when I was travelling and took them the next morning. There does seem to be some margin for error.
If I had to take the medication again (and who knows – I’m waiting for my 12 week SVR results) I would probably take them in the morning to give my memory a better chance. I think the phone alarm is a great idea.
Hi James,
Don’t sweat it too much. I do suggest setting an alarm but you blood levels do this when you take once a day medications:
So you can see they go up and down every day, and increase fast to start with and then slow.
The high point is called the peak and the low point the trough. If you are late with a dose all that happens is that the trough level falls a bit more. Provided that the trough is still above the MIC (Minimum Inhibitory Concentration) then the virus gets no opportunity to capitalise. The standard dose gives you plenty of wiggle room on the MIC and the only circumstance it might matter even a little bit is a long delay in the context of some pretty nasty RAVs.
So, do take it as close to the same time each day as you can, but don’t panic if you’re a bit late, or even if you miss a day (most people do this).
I had one patient – GT2 to be fair so easy to cure – who took his meds for 4 weeks, forgot them for a 2 week holiday, took them for another 4 weeks and then just left the rest in the bottle. Lucky bastard still got SVR12 which seems totally unrighteous, but there you go.
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