Cannabis and HCV

This topic has 54 replies, 17 voices, and was last updated 8 years, 3 months ago by Greedfighter.

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30 April 2016 at 4:08 am #16377
Greedfighter
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- Guardian Angel
@greedfighter
I bought a Volcano vaporizer about 5 years ago. I feel that vaping reduces the tar intake, but does nothing in terms of gum tissue. Even edibles don’t help. It’s an off topic but THC suppresses saliva production, which causes gum damage. Even people prescribed Marinol have this problem. It’s not smoking that ruins yours gums, or the heat, it’s the THC. This is a big problem that gets no press. Lose your teeth, and you can get all kinds of heart problems and infections. It’s the dirty secret of pot.
30 April 2016 at 4:14 am #16378
flyingfox66
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- Guardian Angel
@flyingfox66
Wow! Thats very interesting!
Gum problems is me, thats for sure.
I’d appreciate any links you might have to this issue.
It certainly is a big downside hmy:
edit : Actually never mind about the links, the internet is full of info on this.
Thanks again though, for the heads up.

F49HepC25ysGT1a
mild”
30 April 2016 at 4:22 am #16379
Greedfighter
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- Guardian Angel
@greedfighter
Well here is one I just found on Google

https://sensiseeds.com/en/blog/cannabis-give-cotton-mouth/

There are more. But just to reiterate, I had the same dry mouth problems from ingesting cannabis without smoking. It’s caused by the THC.

Believe me, I love THC But I gave it up after reading so much about it. You won’t have any teeth left if you keep using it!!
30 April 2016 at 4:24 am #16380
mgalbrai
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@mgalbrai
Ahhh..
My “great gums” secret…
Everywhere I go, people say ” Man! You’ve got an awsome set of gums”.,,.
Silver lining I guess.
Quite a few fillings though.
Can’t have everything.

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
30 April 2016 at 4:28 am #16383
Greedfighter
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- Guardian Angel
@greedfighter
Mike you are lucky if you smoked a lot. My gums have been quite damaged from it.
30 April 2016 at 4:35 am #16385
mgalbrai
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@mgalbrai
I wore it out in my younger days.
But those days are long gone.
I had no clue about gum damage due to pot.
I feel for you and the others who are suffering.
Anything that messes with eating is horrible. That I know first hand. When the reflux hits, I am wasted for two days.
Think cookies or brownies would be OK or is it the chemicals in the blood?

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
30 April 2016 at 4:36 am #16387
CJ
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- Guardian Angel
@cj
Nowadays it’s every couple of years or so. I have noticed that I’ve become VERY sensitive to it. Is it because my liver has (had?) more cannabinoid receptors?

I hear it’s got much stronger these days. Because of hydroponics? Maybe that’s why?
x

J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results….pending….
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
30 April 2016 at 4:40 am #16388
Greedfighter
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@greedfighter
It’s actually just the THC itself that is the big problem. People eating brownies. etc. will have the same problems. Fortunately, even though my gums have been damaged, I stopped in time to avoid any long term pain or infection problems. I just have a lot of gum recession. But not a health problem since I stopped in time.
30 April 2016 at 4:45 am #16390
mgalbrai
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@mgalbrai
Happy you got it figured out in time.
I wasn’t making light of your condition. It’s just my weird sense of humor.
We need a “foot in mouth” emoji…
with big feet.

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
30 April 2016 at 4:51 am #16392
Gaj
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- Guardian Angel
@gaj
I hear it’s got much stronger these days. Because of hydroponics? Maybe that’s why?

Yes, it is definitely much stronger mostly due to selective breeding of the best strains, hydroponics just makes that easier to do but even with ‘homegrown’ people tend to use the seeds from the best quality they or their friends have smoked lately. So we are continually selecting for more potent strains.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
30 April 2016 at 4:55 am #16393
Greedfighter
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- Guardian Angel
@greedfighter
No problem. If I had not smoked, I would have drank a lot more and probably had cirrhosis by now. So better to have some gum recession than serious health problems. I feel blessed at this point in time, I really do. I have no regrets. I’m lucky, all things considered.
30 April 2016 at 5:01 am #16394
mgalbrai
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- Guardian Angel
@mgalbrai
Sensemilla-
An Arkansas specialty. Get rid of all the male plants. The females go nuts…
Very potent THC levels….

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
30 April 2016 at 5:14 am #16395
beaches
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- Guardian Angel
@beaches
mgalbrai wrote:

Sensemilla-
….

Latin for without seeds. Literally. True

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
30 April 2016 at 6:35 am #16401
Price
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- Guardian Angel
@price
It’s not about the receptors but the signaling (or lack of) from the receptors.

Receptor expression is usually dynamic – chronic stimulation of receptors often results in decreased numbers of receptors, while under- stimulation causes an increase in the number of receptors. Activation of receptors may also cause modification of receptors to a point where even mild stimuli cause substantial responses. Such changes are not necessarily just alterations in numbers of receptors – types and activities of receptors may also change. Over- or under-stimulation of one receptor can also have profound effects on other receptors.

Things that activate CB1 receptors:
1. Endocannabinoids produced by your own body.
2. Synthetic man-made cannabinoids (like some meds)
3. Plant cannabinoids like marijuana.

“up regulation of CB1 is mediated by increased interferon (IFN) signalling in HCV-infected cells.”
https://sydney.edu.au/mbi/PDFs/Shahidi_SEIB%202011.pdf

Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Endocannabinoid+system+activation+contributes+to+glucose+metabolism+disorders+of+hepatocytes+and+promotes+hepatitis+C+virus+replication.

Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425004/

Recent studies have confirmed the links between the downgrading of cannabinoid receptors in the brain and regular cannabis use. In short, introducing external THC creates changes in the brain. As the body loses CB1 receptors, more THC is needed to create the desired effect.

Cannabis harms the brain. It has a negative impact on dopamine.
http://www.medscape.com/viewarticle/846094?src=trendmd_pilot&faf=1

High-potency cannabis damages key brain structure
http://www.medicalnewstoday.com/articles/303279.php

Cannabis use affects processing of emotions.
“Cannabis appears to have a significant impact on the recognition and processing of human emotions like happiness, sadness and anger”

http://www.medicalnewstoday.com/articles/307249.php
30 April 2016 at 6:48 am #16402
Price
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- Guardian Angel
@price
Greed, weed is associated with insulin resistance and insulin resistance is associated with higher viral load and more rapid damage progression.

P
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