compounding Sofosbivur (& Daclatasvir) by oneself

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23 September 2015 at 1:56 pm #1455
gary
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- Treatment Warrior
@gary
Hello, I have purchased the Sofosbivur and Daclatasvir from Beijing Mesochem and am thinking to compound it myself.

#1. What would be the main excipient needed? Would I only need one excipient? Also, what size capsules would I need – the dosage of Sofosbivur is 400mg per capsule.

#2. I read the post on Daclatasvir but it does not mention the size of capsule so what size capsule would be needed? Thanks very much. Regards, Gary

The list of excipients for Solvaldi are::
Tablet core
Mannitol (E421)
Microcrystalline cellulose (E460(i))
Croscarmellose sodium
Colloidal anhydrous silica (E551)
Magnesium stearate (E470b)
23 September 2015 at 2:38 pm #1456
Alsdad
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@alsdad
Gary, you don’t need to mix the APIs with any excipients, so a size O or OO will do the job. But if you want to mix the APIs with something, lactose is as good as anything else. You will then need the biggest size capsules, OOO, which hold about a gramme of powder.
24 September 2015 at 1:40 am #1459
Alsdad
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@alsdad
Anyway, here is a link to a capsule size chart that I found on Google Image:

http://capsuleusa.com/chart
24 September 2015 at 6:04 am #1460
gary
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- Treatment Warrior
@gary
Thank you for the info, Alsdad. It is much appreciated. Regards, Gary
28 September 2015 at 4:35 am #1506
miko3
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@miko3
Can someone explain why compounding into Capsules is absolutely necessary.
Is there any reason why a daily dose of powder cant be carefully weighed out and taken with say a glass of milk(lactose)?
Obviously care with contamination and moisture penetration would have to be observed.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
28 September 2015 at 7:30 pm #1530
Dr James
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@fixhepc
1. It isn’t
2. It can and it can
Yes, keep it clean, dry and not too hot.

You need the correct dose taken daily. The capsules are optional.

My first patient to reach VL 0 weighed it out daily and swallowed with water.

Capsules are convenient.

Capsules are not cure.

All you need is to swallow enough of the correct meds daily.

YMMV
7 October 2015 at 2:00 pm #1977
Life
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@life
Hello!

How are you?

I have the powder as well from Mesochem…How did it go? You encapsulated them?

Can you give me some details? I just don’t know where to start..haven’t tested them yet…

THANK YOU, I hope you’re doing fine!!!

Life!
7 October 2015 at 2:15 pm #1978
Dr James
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@fixhepc
1. Buy some milligram scales off eBay
2. Buy some size 0 capsules off eBay
3. Measure correct weight, tip into capsule, close capsule
4. Repeat 84 times for each medication
If you are in Australia Buyers Club can both test and arrange encapsulation.

This is a nifty filling tool http://www.torpac.com/funnels.htm

YMMV
7 October 2015 at 2:21 pm #1979
emilio
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@emilio
Hi Life

Where are you? Are you able to get a compound chemist to make up for you? Or alternatively you can get a filler kit and scales etc off ebay etc. There is lots written on here about how to go about filling etc and youtube videos as well. If you are in Australia you can have it tested in Tassie or you could wing it. It probably is from the same batch as mine and others. My batch numbers are in the thead emilio’s place, check it out and see if it’s the same batch? Chances are it will be. I have heard some people aren’t even compounding the powder just weighing it x 12 weeks and swallowing. The DAAs can be taken with or without food and don’t need to be absorbed with fat like ribavirin. Em
7 October 2015 at 3:14 pm #1980
JAKE
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- Novice
@jake
I did exactly as dr Freeman said with the following “improvements”:
1. Instead of buying 1mg scale (which can be expensive) I borrowed one from local manufacturer’s representative. I had to pay deposit.
2. purchased a certified 50mg weight (just to be sure the scale is correct). It is unnecessary but I just wanted to be sure.
3. purchased capsule machine “0” size in case to not keep each capsule in fingers every time i put material there;
4. purchased smallest available glass funnel (standard equipment in laboratories), which fits perfectly into a capsule, and was 4cm wide at the top (enough to put material into a capsule);

I did not use filters, average weight of 1 capsule was 61 mg (out of 96), It took me 4 hours to fill in all capsules.
7 October 2015 at 5:09 pm #1981
gary
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- Treatment Warrior
@gary
Life, I haven’t received my scale yet but the info from Dr Freeman sounds great. The only thing I will do in addition is I have ordered a set of weight for calibrating the scales while weighing the materials. I also purchased a pair of tweezers that are designed for holding the capsules, a small spatula for handling the material and some paper for use when weighing the material – less than 20.00$US for everything. I was thinking to get a capsule machine like Jake wrote in the message below but decided just to do everything by hand – my wife is very patient and kind of likes doing tasks like encapsulating and she has offered to do so. I will not use any excipients as it seems to be an extra (unnecessary) step.

Here are links to the scale and weights I bought. I bought the weights as the scale was not so expensive so I worry a bit about the accuracy.

Good luck. Regards, Gary
7 October 2015 at 6:25 pm #1985
Life
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@life
Ohw ok…Thanks…I’ll try to encapsulate it..I just found an explination on this forum a couple of weeks ago, it seemed so complex…
I’m from Belgium! So if anyone is interested to Skype me or so.., I’m sorry but… would be nice.
But I’ll also check your forum…

I haven’t got it tested yet…don’t know I’ll see if it will be possible…

I ordered Dac back in August that’s probably why I still got the Sofos after…hope they wre honoust…Thanks!!!!
7 October 2015 at 6:30 pm #1986
Life
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- Guardian Angel
@life
Thank you!!! You’re right about precision!!!
It seems so complex…and where do you get the other ingredients and stuff…or I’m asking a stupid question…

I’ll read everything precisely…

Good luck to you all!!!!!!!!
8 October 2015 at 7:50 am #2006
gary
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- Treatment Warrior
@gary
Life, you do not need any other ingredients. Just put the medicine in the capsules and take them as is. Here are some links for the paper, capsules, tweezers, etc. I bought my goods from Amazon Japan so the links below are some examples only in English for ease of use. The tweezer link is to amazon japan as I could not find tweezers on amazon USA but you can see the picture to get an idea of the tweezers.

You don’t need 1000 capsules so search for a box/bag of 100 for each medicine – total 200, though you only need 2 x 84 = 168 for 12 weeks treatment. I bought two different types of capsules, one for for each medicine, just to keep things a bit easier to track.

The glassine weighing paper may not be necessary but it was cheap and easy to get in Japan so I bought it.

http://www.apothecaryproducts.com/pharmacy-supply/compounding-supplies/balances-scales/weighing-accessories/glassine-weighing-paper.html

This is just a link to a spatula/spoon. You will need to decide which size you want to buy.

You probably do not need anything other than the capsules but my wife requested the other goods for ease of use. I also have a very small funnel in case filling the capsules directly from the paper proves difficult. You will need to decide for yourself how you want to proceed with the encapsulating and buy the necessary tools. Best of luck. Regards, Gary
8 October 2015 at 11:59 am #2012
Life
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- Guardian Angel
@life
Just One question before the week-end…:

Can I swallow them both at the same time? Breakfast…? Fatty food or not…?

THANK YOU FOR ALL YOUR HELP!!!!!!!!!!!
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