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Hi LG,
In simple terms Daclatasvir is metabolised in the body by the CYP3a4 enzyme, as are many other drugs. How well CYP3a4 metabolises drugs like Dac is effected by other drugs and foods we eat and drink. if something causes it to metabolise the Dac quicker like Taurine then it is an inducer and we don’t get the full dose and if it makes it less effective like Grapefruit or in this case Grapes then it is an inhibitor and we get too large a dose of Dac and more sides.
https://en.m.wikipedia.org/wiki/CYP3A4
On the other hand Ledipasvir isn’t metabolised by CYP3a4 but has absorption issues depending on acidity levels in the stomach.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Radtek,
If you check my post on the previous page, I was greedily
eating 5-6 big handfuls of grapes per day. The effect was mild but noticeable. I don’t know how many raisins your Raisin Bran has in it but doubt it would be anywhere near the level I was eating. If you are still worried eat it at the opposite end of the day from the meds and maybe think about alternating daily with a different cereal/bran that doesn’t have raisins.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Most foods are Ok but I try and not have an abundance of anything and just eat normaly. If you arn’t having any side effects and the meds are working your probably ok.
cheers
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated
GT 3 – about 28 yrs with HCV
Coffee is not an inhibitor or inducer of CYP3a4 went taking Daclatasvir. I suspect pat1 just meant that coffee didn’t agree with her while on treatment. One common item that may be a problem is Taurine which is found in many energy drinks and health supplement type things.
http://fixhepc.com/forum/experts-corner/714-taurine-daclatasvir-and-treatment-failure.html#10953
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
A recent study of Daclatasvir interactions funded by BMS and including the following conclusion.
The robust characterization of the DCV clinical pharmacology program has demonstrated that DCV has few or no clinically relevant DDIs with medications with which it is likely to be co-administered, and the majority of DDIs that do occur can be predicted and easily managed.
http://link.springer.com/article/10.1007%2Fs12325-016-0407-5
Probably not a great deal of new information for those who have read this site extensively but it does officially confirm the Taurine found in many energy drinks as something to be avoided as suggested by Dr Freeman.
In addition to herbal and dietary supplements which may increase DCV exposure via CYP3A4 inhibition, others may induce or modulate the induction of CYP3A4 and thus potentially reduce the antiviral activity of DCV. Such extracts include St. John’s wort (Hypericum perforatum; a strong inducer of CYP3A4 and thus contraindicated for concomitant use with DCV) [36] and taurine (commonly found in body-building supplements and energy drinks) [38].
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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