Darvoni story - FixHepC

This topic has 15 replies, 8 voices, and was last updated 8 years, 5 months ago by fitz.

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5 June 2016 at 12:05 am #18400
Hazel
- Topics: 45
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- Total: 414
- Guardian Angel
@hazel
Excuse cross postings of these, but this was news to me, and a great story. Further evidence if you need it of the impact Dr J is having on the world: https://www.hepmag.com/blog/italian-job-good-news

Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
5 June 2016 at 12:58 am #18405
beaches
- Topics: 10
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- Total: 760
- Guardian Angel
@beaches
Doctor James is a hero and is being treated as a petty criminal by the Australian thugs who call themselves a government

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
5 June 2016 at 1:55 am #18406
Vororo
- Topics: 25
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- Total: 332
- Guardian Angel
@vororo
Hazel wrote:

Excuse cross postings of these, but this was news to me, and a great story. Further evidence if you need it of the impact Dr J is having on the world: https://www.hepmag.com/blog/italian-job-good-news

And just for completeness, Beacon have made an absolutely superb web site specifically for Darvoni:

http://www.darvoni.com

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).
5 June 2016 at 8:41 am #18423
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
And the best part….Darvoni is unlicensed!
5 June 2016 at 8:42 am #18424
beaches
- Topics: 10
- Replies: 750
- Total: 760
- Guardian Angel
@beaches
Looking at their site it seems you can just fill in a form and order the meds. Is that right?

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
6 June 2016 at 7:22 am #18483
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
Is it true doc James gave the name darvoni
6 June 2016 at 8:37 am #18491
Dr James
- Topics: 264
- Replies: 1,968
- Total: 2,232
- Guardian Angel
@fixhepc
It was one of the names I suggested back in October last year when I was asking companies in Bangladesh take advantage of their ability to produce it, but the notion of Sofosbuvir+Daclatasvir as the single pill pangenotypic cure for the world belongs to Dr Andrew Hill.

Both Beacon (Darvoni) and Incepta (Corevigen) had the foresight to produce this product and it would be great to see it widely deployed.

———- Forwarded message ———-
From: GP2U Telehealth
Date: 1 October 2015 at 21:44
Subject: Re: sofosbuvir
To: Tamal

Thanks Tamal,

Can I make suggestion.

Make a combined tablet called Darvoni or Daclovir or Diclovir or >>>>> Duovir <<<<< I like this name Sofosbuvir 400 + Daclatasvir 60 This product will be market leader in 1 year. This single tablet is the product the world needs. I would like box to contain 28 tablets (not 6 like Twinvir - that is silly number 14 boxes for 1 course of treatment!) 2 boxes == 8 weeks treatment 3 boxes == standard 12 weeks treatment Kind Regards James

YMMV
6 June 2016 at 9:01 am #18492
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
If the product is not licenced does that mean you dont need a prescription to import drugs to Australia. Cost is reasonable.

I paid $ 2700 usd for 12 months supply from Natco India so not having to fly over and get 48 weeks for $ 2800 usd seems ok.

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
6 June 2016 at 9:09 am #18493
Dr James
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- Guardian Angel
@fixhepc
The prescription requirement in most countries relates to the fact that possession of a scheduled prescription only medicine is an offence without a prescription. So if you look at Australia it’s legal to bring it in, but you become a felon taking possession (without a prescription).

In New Zealand transiting customs requires that a local NZ prescription exists so the rules vary from country to country.

YMMV
6 June 2016 at 9:21 am #18494
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
So I can import it into Australia as long as I have an Australian prescription.

I just thought when it said Darvoni wasn’t licenced it would be legal in Australia without one.

Customs told me that with the sof / dac I only needed any Doctors Script as I thought I needed a Specialist. I ended up getting a Specialist to write it and they put on it to take 2 morning and night and the Liver Surgeon in India had no problems getting that amount through him for me. It was ordered 11am and delivered to my hotel at 7pm that night by the rep.

It looks like I better check customs again as 2 different times I was told the above.

Thanks for the reply Doc.

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
6 June 2016 at 11:08 am #18501
Dr James
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- Guardian Angel
@fixhepc
I ended up getting a Specialist to write it and they put on it to take 2 morning and night

There are no DAAs where the prescription is take 2 in the morning and 2 at night other than Ribavirin where that would make sense.

What genotype are you, level of fibrosis, and what have you been prescribed?

YMMV
6 June 2016 at 11:42 am #18504
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
Sorry Doc I think I better stop posting as I dont seem to make sense.

I only take 1 per day and my Doc/ Spec just wrote the script so i could get 12 months supply as the majority of custom officers wouldn’t really know the real dose.

Not 100% on what fibrosis etc as I get confused with the number and will check it.

Regards Barry

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
7 June 2016 at 8:58 am #18574
beahavan
- Topics: 5
- Replies: 81
- Total: 86
- Guardian Angel
@beahavan
I have emailed Beacon Industries and am waiting to see if I can get Darvoni without a prescription in USA.

G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
7 June 2016 at 11:23 am #18598
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
They told me I am hep c genotype 1a Cirrosis.

Pretty easy mob Darvoni to get answers from as emailed them yesterday and answers within 5 min all good.

Just need an australian script to get it through customs legally.

Regards Barry

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
7 June 2016 at 8:49 pm #18629
beahavan
- Topics: 5
- Replies: 81
- Total: 86
- Guardian Angel
@beahavan
Md Shahariar Tamal Selim gave me the email address of someone who supposedly got the Darvoni in the USA. I emailed but am not sure if he was saying that he actually got the drug? Very vague response. Not too helpful. One does need a prescription in the USA. Does anyone know of a real world success?

G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
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