generic daklinza in 100 countries?

This topic has 4 replies, 5 voices, and was last updated 9 years, 11 months ago by LondonGirl.

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24 November 2015 at 7:03 am #4547
2b
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- Guardian Angel
@2b
Don’t know if this is new news or not, but it was dated today in this article,

http://www.bloomberg.com/news/articles/2015-11-23/bristol-myers-lets-low-income-countries-copy-hepatitis-c-pills

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
24 November 2015 at 7:17 am #4550
coral
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@coral
Hi 2b,

At face value it looks as if Bristol-Myer are trying to take a more reasonable, broad and humane approach to the treatment of Hep C. I imagine there must be some hurdles to jump to do any collaborating with Gillead. Good to see the increasing media focus on Hep C and the broader distribution.

Coral
24 November 2015 at 8:24 am #4553
Gaj
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- Guardian Angel
@gaj
Yes, looks like it is news, and good at that.

This will allow manufacture of a combination Sofosbuvir/Daclatasvir single pill similar to Harvoni or Twinvir (Sofobuvir/Ledipasvir) which hasn’t been available till now. So single pill treatments available to cover all genotypes soon now I believe.

Only for developing countries but will simplify treatment in those areas and presumably cheaper as Dac is much less expensive than Led.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
24 November 2015 at 10:48 am #4558
darbara
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- Guardian Angel
@darbara
Yes this is news.

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
24 November 2015 at 1:13 pm #4561
LondonGirl
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@londongirl
Hi 2b, Yes just read this on Twitter, has to be a positive

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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