Generics Late Breaker Accepted for EASL in April

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16 March 2016 at 3:02 pm #13927
Dr James
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- Guardian Angel
@fixhepc
While the content is under embargo (so I can’t spill the beans yet) I am happy to report that the adventures of the generic rebels will be presented at EASL as a late breaker on 16th April 2016.

To that end if you are one of the people who we are tracking getting your bloods done will ensure your results form part of the data set.

If you are past EOT and coming up to or past SVR4 and have not had those bloods done yet the clock is ticking…..

YMMV
16 March 2016 at 9:14 pm #13933
Sirchinenge
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@sirchinenge
Excellent. I updated my own results with my close to four week SVR

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
17 March 2016 at 12:57 am #13944
Vororo
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@vororo
Great stuff!!

As soon as I get my latest VL results (EOT + 4 Weeks and a bit) I will upload to GP2U…

Sock it to them, Dr James!

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).
17 March 2016 at 5:09 am #13966
Dr James
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@fixhepc
Hi Sir,

Sadly SVR2 does not count! Close but no banana….

We expect the results to be closely looked at and thanks to Hieu they are squeaky clean with the before, during and after results clearly documented on paper.

One of the good things about HCV and generics is that it’s so clear cut: now you see it, now you don’t. The LFT results usually come in a “this is clearly before” and “this is clearly after” set of 5 or more on one page but it’s hard to argue with the HCV RNA not detected.

We can see from the forum that the safety profile/side effects are in line with expectation, and it’s not like we censor anybody.

There will be some interesting observations reported that will have global utility fighting this disease.

YMMV
17 March 2016 at 6:05 am #13973
zhuk
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@zhuk
EOT 7 days and counting

But alas, that puts me outside the April 16 deadline for furnishing SVR4….damn

If i’d known I would not have held onto the meds for a whole month before starting /facepalm lol

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
17 March 2016 at 7:03 am #13985
2b
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@2b
my dr wanted to wait for next test until 12 weeks, but I’ll try and get one next week in which case it will be an 8 week + a little, results should be back before April if i can get another test out of them.

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
6 April 2016 at 9:30 pm #14991
mgalbrai
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@mgalbrai
EASL update!!

http://hepatitiscnewdrugs.blogspot.com/2016/04/hepatitis-c-in-limelight-again-at-liver.html

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
6 April 2016 at 11:20 pm #14993
Debs
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@debs
Great!
Go Dr Freeman!
(Wish I could have hit the deadline for SVR 4 results, but not possible.)
Deb X
7 April 2016 at 12:23 am #14997
Hazel
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@hazel
Excellent! will post this link around a bit. Draw a big audience, I would think so

Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
8 April 2016 at 3:09 am #15042
Jaz
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@jaz
I just got my 4 week post EOT results – undetected! Can I contribute my data towards this? I got my meds through kingswood and have only seen my liver clinic so I’m not sure what I need to do to get mine included…

3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx – ALT 71 AST 40 V/L 9 million
Day 11 – ALT 12 AST 15
4 week – LFTs normal – detected (same sample sent for v/l showed undetected) :/
6 week – UND
12 week EOT – UND
SVR4
SVR12
8 April 2016 at 3:17 am #15043
mgalbrai
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@mgalbrai
Congratulations!

The doc is probably checking these posts from afar, but I emailed them to him all the same.
Can’t hurt.
Happy for you!
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
8 April 2016 at 3:41 am #15045
LondonGirl
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@londongirl
Dan also got his 4 weeks post UND today too (in case anyone’s reading)

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
8 April 2016 at 5:59 am #15056
Jaz
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@jaz
Thanks Mike! I appreciate that!

And congrats to Dan if he sees this!

3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx – ALT 71 AST 40 V/L 9 million
Day 11 – ALT 12 AST 15
4 week – LFTs normal – detected (same sample sent for v/l showed undetected) :/
6 week – UND
12 week EOT – UND
SVR4
SVR12
8 April 2016 at 6:32 am #15057
Hieupham
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- Recovery Champion
@hieupham
Hello Jaz,

Thank you for posting your result.
For Dr. James’ record, did you have INF before? Your fibroscan was F0?

Nishkama Karma
C√πng nhau lo·∫°i b·ªè Vi√™m gan C tr√™n kh·∫Øp th·∫ø gi·ªõi!
8 April 2016 at 6:59 am #15058
Jaz
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@jaz
Hi Hieupham,

Yes, my fibroscan was F0 around 1 year ago.
I have not had any previous treatment.

Let me know if you need anything else.

Jaz

3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx – ALT 71 AST 40 V/L 9 million
Day 11 – ALT 12 AST 15
4 week – LFTs normal – detected (same sample sent for v/l showed undetected) :/
6 week – UND
12 week EOT – UND
SVR4
SVR12
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