The reversing fibrosis article almost reads like the affects of DAA’s may be generalised across all the body’s bits ….

“Recent clinical trials have shown that curing hepatitis C with antiviral medications often results in a dramatic resolution of the dense fibrosis that accompanies cirrhosis — far more than previously thought. This shows that fibrosis can be reversed.

Realistic strategies for deactivating myofibroblasts have opened up the theoretical possibility that medications or other therapies might halt and even reverse fibrosis — at least in the test tube. Other biochemical pathways that regulate the process of remodeling also seem to be open to therapeutic alteration in the laboratory.”

I didn’t get a sense of how this all worked, but it sounds possible DAA’s may have other unintended uses…? Does it breakdown the fibrosis or just give the liver a fair go at doing this?

I read somewhere about good old interferon possible being effective in reversing Peyronie’s disease in as much as it broke down scar tissue??

It is something with treatment I was hanging my hat on; and it’s good to see an article holding out some hope that getting rid of the bug may help with scaring as well.

Yours

Jeff

This article isnt from the Blogspot but a good article nonetheless.

http://www.snopes.com/hepatitis-c-drug-prices/

I don’t know if this has already posted here or somewhere else in the forum (sorry if it has)
I just received in an email this am.
http://www.upi.com/Health_News/2016/04/17/Study-Generic-hepatitis-C-drugs-as-effective-as-brand-names/1601460939760/
Note the comments at end of article

So if someone has had HCV and now has very advanced fibrosis and has had a liver cancer that will come back and they don’t have enough unaffected liver to regenerate, could these DAAs help repair their fibrosis?

Hi beaches,

My reading of the available evidence is that the DAAs remove the HCV and the absence of HCV reduces inflammation. Inflammation is what causes fibrosis and eventually HCC. So if inflammation is reduced and fibrosis is not being created then the liver has a better chance of regenerating and there is less risk of HCC forming. If you have enough healthy liver to currently support you then there is an opportunity for it to regenerate. The problem is when your liver can’t support you from day to day, at that point you need a transplant anyway, although no longer having HCV thanks to the DAAs means your new liver won’t get infected.