Home › Forums › Main Forum › Experts Corner › Viral Load and SVR › HCV Viral Load and Speed of Decline Do Not Predict Cure

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  • 5 March 2016 at 3:38 am #13324
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Direct-acting antiviral regimens containing sofosbuvir (Sovaldi) and the drugs in Viekira Pak were highly effective regardless of how soon HCV viral load became undetectable after starting treatment, according to research presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI). Furthermore, even having low-level detectable HCV RNA at the end of treatment does not preclude a cure, the investigators for a related study concluded.

    http://www.hivandhepatitis.com/hcv-basic-science/5160-croi-2015-hcv-viral-load-and-speed-of-decline-do-not-predict-cure-with-interferon-free-therapy

    YMMV

    5 March 2016 at 3:51 am #13326
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he’d failed only to go on to clear at 3 months post tx – Interesting. Is there ‘any’ sort of pattern appearing?

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    5 March 2016 at 7:40 am #13342
    Avatar photoTina-Hill-facebook
    • Guardian Angel
    • ★★★★★
    @tina-hill-facebook

    Love this article

    Yes LG I too wonder whether the current EOT and SVR 4 result for Redemption are mirroring what we read in the conclusion of this study, time will tell.

    Its reassuring for me to have read this as I am still detected <12 upon the EOT (Abbott Real Time Assay). I am hopeful that I too will follow the trend as suggested by the author. If that is not the case at my EOT + 4week VL then I will retreat using a alternative DAA regime with an extended tx period from my first round.

    Interesting ride ahead awaits me.

    SVR 24

    5 March 2016 at 10:23 am #13349
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    yes no panic :)

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    5 March 2016 at 10:35 am #13353
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara
    LondonGirl wrote:

    Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he’d failed only to go on to clear at 3 months post tx – Interesting. Is there ‘any’ sort of pattern appearing?

    Yes if you see the US forums there are many examples of this kind of pattern where detected EOT and at 4 weeks EOT but got SVR 12

    Even for the doctors these are new drugs and their experiences are limited. The article is a year old but glad its here just reduces the anxiety and panic.

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    7 March 2016 at 2:28 pm #13466
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Just read this (Tina) xx

    http://hepcukforum.org/phpBB2/viewtopic.php?p=173731#173731

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    7 March 2016 at 3:23 pm #13469
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    http://forums.hepmag.com/
    Many many stories like this there

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    7 March 2016 at 6:34 pm #13474
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Had a chat with my friend previously mentioned, he said he was Detected 15 at EOT , then a few weeks post EOT VL rose to 50, but at week 12 post tx he was UND.

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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