Is it safe to take DAAs after breast cancer successfull treated

This topic has 4 replies, 3 voices, and was last updated 5 years, 8 months ago by Songbird.

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23 February 2019 at 11:43 pm #28992
Radover
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@radover
My aunt had breast cancer and she did Mastectomy, after that she had Chemotherapy and the result was that she is completely treated.
Now she found out that she has Hep C. Is it safe to get treated using antivirals like (sofosbuvir+daclatasvir or harvoni) now?
She finished her chemotherapy about a year and 10 months ago. Her liver is in a good shape except for a little bit of fatty liver (not much).
Thank you in advance.
25 February 2019 at 2:39 am #28994
Dr James
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@fixhepc
Hello Radover,

Your aunt will have no safety issues taking antivirals. You can actually give them at the same time as chemo and the SVR12 (cure) rate is the same for the Hep C.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123740/

With a liver in “good shape” the treatment should be straightforward.

For most patients with Hep C treatment delivers meaningful real-time improvements in quality of life as well as long term benefits.

YMMV
25 February 2019 at 5:19 pm #28998
Radover
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@radover
Thanks DrJames for your answer. I hope everything goes well with her.
26 February 2019 at 9:40 am #29000
Dr James
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@fixhepc
Beating breast cancer can be hard. Compared to that, with the new direct-acting antiviral medications, Hep C is a pushover!

YMMV
2 March 2019 at 8:57 pm #29008
Songbird
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@songbird
My situation very closely mimicks your aunts.

I treated successfully breast cancer in 2016 with surgery, chemo and radiation
Then 2 yrs. later treated my HepC successfully with a DAA regime and everything went well .
Both my Hepatologist and Oncologist advised me at the time there would be no safety issues .

Good luck to her.

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!
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