One of the doctors on Research Gate says that since sofosbuvir is a 5fluoro uracil- like compound (5FU is a chemotherapy drug) then you can expect that side effects would be the same although in a much lesser degree, all side effects listed for 5FU are likely to appear….(and side effects include skin redness, plus delayed cancers and cardiac problems.)

Here’s the conversation
https://www.researchgate.net/post/any_suggested_papers_about_respiratory_side_effects_of_sofosbuvir

P

I see it a different way Beaches.
As Dr Ponzetto said sof IS a 5fluoro uracil-

“Sofosbuvir is a phosphoramidate prodrug that is metabolized in the liver to β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate.”

https://www.dovepress.com/changing-the-face-of-hepatitis-c-management-ndash-the-design-and-devel-peer-reviewed-article-DDDT

Knowing exactly what you’re taking can help prevent, identify and treat side effects. For example, the literature says that skin redness can be helped by Pyridoxine (Vitamin B6). Obviously, everything should be checked with your doctor.

https://books.google.com/books?id=CDADMzS0TKUC&pg=PA161&lpg=PA161&dq=5FU+and++cutaneousYHXuc2V0&hl=en&sa=X&ved=0ahUKEwi5qqnnhJLOAhUUT2MKHc4fArwQ6AEISTAG#v=onepage&q=5FU%20and%20%20cutaneous%20toxicity&f=false +toxicity&source=bl&ots=dNje7r1NGT&sig=RhgFPgLWtnXjAHO_po-

No, he did not! He stated “since it is a 5Fluoro-Uracyl -like compound”

“Is” and “like” are not interchangeable words particularly in this sort of discussion.

“Sofosbuvir is a phosphoramidate prodrug that is metabolized in the liver to β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate.”

https://www.dovepress.com/changing-the-face-of-hepatitis-c-management-ndash-the-design-and-devel-peer-reviewed-article-DDDT

I just want to make sure that readers realise that while the above quote and citation are fine they are not attributable to A. Ponzetto.

Knowing exactly what you’re taking can help prevent, identify and treat side effects. For example, the literature says that skin redness can be helped by Pyridoxine (Vitamin B6). Obviously, everything should be checked with your doctor.

https://books.google.com/books?id=CDADMzS0TKUC&pg=PA161&lpg=PA161&dq=5FU+and++cutaneousYHXuc2V0&hl=en&sa=X&ved=0ahUKEwi5qqnnhJLOAhUUT2MKHc4fArwQ6AEISTAG#v=onepage&q=5FU%20and%20%20cutaneous%20toxicity&f=false +toxicity&source=bl&ots=dNje7r1NGT&sig=RhgFPgLWtnXjAHO_po-

Very true but “knowing exactly” is the important point and Sofosbuvir is not exactly 5Flouro-uracil so you should not be extrapolating treatment from one to the other. Your advice about checking with a doctor is sound.

I would also like to point out that in your original citation A. Ponzetto goes on to comment about the toxic excretions of bacteria (h.pylori) that at least 50% of the human population carries in our digestive systems and also about the levels of chemotherapy type molecules in the food and water most of us eat and drink. My reading of that is that he is not trying to scare us but to point out that many items we ingest carry some very, very small element of risk but many benefits and Sofosbuvir fits in that category.

We know that Sofosbuvir may have some side effects and very occasionally a patient may have more serious adverse events, that has been well documented. However, it does not mean that every event that occurs while on treatment relates to that treatment. In JamesF’s instance he has a reddening of the skin, it may be from Sofosbuvir but then again millions of people worldwide get rashes everyday without taking Sofosbuvir. He has wisely sought medical advice and both his specialist and Dr James have suggested monitoring as appropriate at this point, I’ll back medical opinion.

So if you’ve got issues with symptoms and side effects and want some suggestions on how to moderate them, then go elsewhere, because this is the land of the magic cure for which we should all be eternally grateful?
I guess I’m not part of the royal We because I’d like to know what the hell to do to pull myself back out of this back slide.
I’m doing all the obvious stuff. I can’t see me working again any time soon if I don’t improve.
Maybe Price doesn’t have any answers but at least she doesn’t imagine we’ve all been eating candy floss.

As for suggesting the side and after effects are a coincidence…lol!
I can pay GPs to look at me like I’m crazy…I don’t need that from fellow travellers.

Hi flyingfox66,

I’m sorry to hear you are having issues post treatment. None of my post was in response to yours as I am not qualified nor have the experience or knowledge to to make suggestions regarding your particular symptoms.

However, I do have experience of disbelieving doctors as I am sure do many others here. My suggestion based on that experience would be to seek another, more empathetic opinion.

Edit: beaches probably states it better than me.