REDEMPTION-2 and 3 Timelines

This topic has 17 replies, 10 voices, and was last updated 8 years, 5 months ago by fitz.

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18 October 2015 at 2:09 pm #2444
Dr James
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- Guardian Angel
@fixhepc
Here are the current timelines:

16th November: RVR Medications start being taken by patients (in process) The first patients are taking trial medication for 1 week to assess Rapid Virological Response. They will then continue on with a full course of medication that has already be proven effective

23rd Novenber: Day 7 viral load testing

1st December: Trials subscriptions will open (based on satisfactory RVR results)

26th December – Medications will start shipping to patients

January-February-Mar: 12 week treatment window

April 13th-17th: On treatment and EOT results reported at EASL Barcelona

The results for patients on 24 weeks treatment and the SVR4, SVR12 and SVR24 rates will be reported across the course of 2016.

YMMV
21 October 2015 at 12:36 am #2562
Jolie
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- Guardian Angel
@jolie
hello Doc James ,

I have a question concerning the timeline for those trials, you state:

December-January-February: 12 week treatment window

does this word “window” means one can start anytime in December, like after Xmas? or even January after New Year?
or are all participants supposed to start on the same day like 01 December 2015 ?? & be done by the end of Feb?
– assuming we’re talking duration tx of 12 weeks.

I’m trying to work out the best options amongst all sorts of prior commitments already made for December, etc

Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA – UND. – down from 2 ML
9 weeks HCV PCR RNA – UND.
21 October 2015 at 7:55 am #2577
Dr James
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@fixhepc
Hi all, can someone in the US take part in the trials?

YMMV
21 October 2015 at 8:02 am #2578
Dr James
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@fixhepc
I am a newbie, have been reading and reading all the info. Have had Hep C at least 30yrs. GT1a, 15 million VL, 139 and 229 LFT. getting a fibro scan this week. No prior TX. Losing weight and feeling a bit scared. I doubt Medicare will come through for me and considering a trip to Hobart. I love being able to hear your stories and have hope thanks to all of you.

YMMV
21 October 2015 at 10:57 am #2582
crazy8
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- Recovery Champion
@crazy8
Hi Jan, If you can get to Australia then do it, don’t wait for the bean counters to say that your now sick enough for the meds (or for current regulations to suddenly change), snatch your own wellbeing away from dollar driven indifference and reclaim your life.

GL

GT 3, F3, Contracted 1993 Tx Naive
V/L 1,267,000 AST 67 ALT 65 6/10/15
commence Sof/Dac (Mesochem) 6/11/15
AST ALT normal 24/11 *
*V/L UNDETECTED 24/11*
21 October 2015 at 4:22 pm #2595
Dr James
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- Guardian Angel
@fixhepc
The world exists as we find it. I dream of better, work with now, and aim for the future…

YMMV
21 October 2015 at 5:20 pm #2598
Enkel
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- Guardian Angel
@enkel
Yeah, work with now to take meds, the others come itself

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
2 November 2015 at 1:56 am #3181
Felix
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- Novice
@felix
Hi Jan

My situation is very similar to yours. I made an appointment with Dr James Freeman at:
https://gp2u.com.au/

I recommend that you do the same to talk over your options with him.

Most of all, don’t be afraid.
5 November 2015 at 8:57 am #3355
Dr James
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- Guardian Angel
@fixhepc
Hi Felix, Thank you for the encouragement. Are you from the USA too? Are you getting treatment?

YMMV
2 December 2015 at 11:18 am #5035
zhuk
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- Guardian Angel
@zhuk
Count me in as now ready for the trials…my meds arrived yesterday

Amazing to think how much $ is represented in those two innocuous bottles…I feel incredibly fortunate to have this chance at a cure (and to those who have done so much, you know who you are and what gratitude is owed…and immeasurable thanks to Dr J)

Now, to wait for January…patience not being my strong suit lol

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
2 December 2015 at 2:03 pm #5048
LondonGirl
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- Guardian Angel
@londongirl
So end of December is the next one?

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
2 December 2015 at 4:12 pm #5060
zhuk
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- Guardian Angel
@zhuk
Dr James amended his initial post here, LG…now its from Jan-thru-March. I’m guessing the RVR trials bumped the timeline forward a bit

http://fixhepc.com/forum/redemption/209-redemption-2-and-3-timelines.html#1394

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
17 February 2016 at 8:22 pm #12120
Dreamer
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- Novice
@dreamer
Hello Dr James,
How long need to wait to be approved and receive medicine ( Sofosbuvir 400mg/Ledipasvir 90mg) if apply for The REDEMPTION-3 eTrial? What another way to get these medicine?
Thanks!
18 February 2016 at 2:36 pm #12171
Dr James
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- Guardian Angel
@fixhepc
Basically as long as it takes you to fill in the trial agreement form, for the money to clear (3 days) and then the medication to ship (5-7 days).

Typically under 2 weeks from apply to receive.

YMMV
22 April 2016 at 10:35 pm #16039
Matt-Kenney-google
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- Guardian Angel
@matt-kenney-google
Hello Dr.Freeman,
I finished registering and wired payment from USA for Redemption 3 eTrial and was curious about your statement, “Typically under 2 weeks from apply to receive.”
Does that still hold true for us here in the US?
I’ve yet to be contacted for consult with Indian doctor as I just wired yesterday from US bank to bank in Aus.

Thank you,
Matt

GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”
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