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Maybe we should be adding 60 days of Ribovarin then Doc ?
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated
GT 3 – about 28 yrs with HCV
Hi Ann,
I’ll try to answer this to the best of my knowledge based on laymans understanding of what I have been told. (Anyone else please jump in and correct me if I got it wrong).
The PCR/RNA test used to determine viral load doesn’t actually count the number of virions present in your blood but rather the levels of viral genetic material (RNA) present. This allows a calculation of approx levels of viral load which could be say 2 million or UND or < 15. 1. Obviously 2 million is fairly high and would indicate active virions replicating, otherwise your body's garbage system would be reducing the load. 2. UND means that the test was unable to detect RNA but it doesn't actually mean that no viral RNA is present anywhere in your body. However it does tend to indicate that the virus is probably eradicated and is certainly not actively replicating at the moment.
3. < 15 means that some RNA was detected but your load is below the tolerance accuracy of the equipment. But the thing to remember here is that the measure is RNA rather than viruses. So if you reach SVR12 at UND or < 15 then while some RNA is still being detected, there is no evidence of viral replication during the 12 weeks since treatment as the expectation would be that this virus replicates quite quickly. This would tend to indicate that the viruses have been "defeated" or "killed" even though some of it's genetic materials are still present in your body (sort of similar to the way that scientists can find DNA from wooly mammoths even though they have been extinct for millennium) and so you are considered "cured" for the purposes of the trial. The point to make here is that the only way to fully determine if someone has truly been "cured" is to follow them and test them for the rest of their natural life which is no use for the trial as we need results within our lifetime. But the good news is that the odds say that if SVR12 or better SVR24 have been achieved then the chance of relapse is extremely low to almost non existent.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks for clarification and correction Dr James.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Bloot,
See below link. Post three where Dr James seems to be saying that you need a minimum of 60 days with Riba for full effect.
http://fixhepc.com/forum/questions-and-answers/300-to-riba-or-not-to-riba.html
I know my specialist wants me on it for as long as possible because my liver is definitely work hardened.
inch: G
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks Gaj
That’s a bummer
I’ve got about 9 weeks (-4 weeks for delivery) to make a decision
I’ll see how my results go an play it by earJust looked at the new pricing
My next course of sof/ dac is down so i can get a course of riba and still be under what it cost previously
Then I can make the decision at week 12 to finish out the 24 including the riba
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