But what if you have a patient who’s insulin resistant? Then you have mitochondrial degeneration and declining ATP status
Normal mitochondria react to insulin by boosting production of ATP, by 90 %. But the mitochondria from insulin-resistant people only boosts ATP production by 5 % and you need ATP to make SAMe (plus Ribavirin also depletes ATP).

Selenium, Co-Q10 and Vit C are mitochondrial antioxidants. Plus, Vit C reduces the risk of gallstones (which is sometimes a problem during treatment).
.
PP

I believe that insulin resistance promotes anemia.

Ribavirin is taken into the red blood cells where it is converted to ribavirin triphosphate. Since red cells lack the enzymes needed to hydrolyze ribavirin triphosphate, it is “trapped” in the red cells, where it depletes the cells’ ATP. The resulting ATP deficiency impairs antioxidant defense mechanisms and induces oxidative membrane damage on the red cells, causing hemolysis….end result…anemia

Normal mitochondria react to insulin by boosting production of ATP by 90 %. But the mitochondria from insulin-resistant people only boost ATP production by 5%.

So that would mean that insulin resistance promotes anemia, right? Or maybe it means I have too much time on my hands to come up with wild theories, :unsure

PP

Wow! There’s a lot to take in here. Very interesting about the cholesterol and VitD – over the last couple of years my cholesterol has been steadily rising to be considered ‘high risk if history determines’ – no explanation regarding diet etc and I was freaked out! MY previous DR got me to collect family history, diet check etc and assumed it was because my liver wasn’t functioning properly due to HCV; but my current Dr said could be genetic predisposition to high cholesterol, don’t worry.
My Vit D levels were marked as being way too low and hence I included a Calcium/D supp. My symptoms have been worse over past couple of years re HCV, now wonder if cholesterol levels and low D have been involved??

Debs, I too have been suffering terrible hair loss & dry skin, again last couple of years. I take Vit B complex for it.
Naturopath recommended Vit C for Hep C – though the form of it was specific (forget now??) I was suffering bleeding gums and easy bruising. I take Vit C with Zinc powder occasionally for boost. I read the articles and posts here and now I’m confused.

Hi Chejai, Im with you on the hair loss

About the Vit C, Dr f earlier in the thread says;

Yes to B12 and D

No to retinol, C, E, K and selenium

fixhepc.com/forum/experts-corner/566-sup…-hcv-viral-load.html

LG it’s great to read that you have an appetite for food now can only be good for you

I use Swansonvitamins brand products for the most part. I have very good reason to trust there products and you will not find cheaper. I use there 300mg ALA a few times a day. There are always buy 1 get one free for it. Get on there mailing list.

Hi all, I won’t take anything but Lamberts, quality & price. There is another goOd make the name escapes me, but it’s very pricey.
Dr F said ALA is fine on treatment.
Best, LG

Hey CC2B – it’s in there somewhere
I think quite near the beginning