SVR 24. détected again

This topic has 19 replies, 15 voices, and was last updated 8 years, 4 months ago by Matt-Kenney-google.

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29 July 2016 at 10:25 am #21586
jeanmarc
- Topics: 2
- Replies: 9
- Total: 11
- Acolyte
@jeanmarc
I finished my 3 monts treatment with twinvir 6 months ago and got a non detected result!
yesterday I got the result of my new viral 6 months after EOT and it’s detected again
So what I should do now ?
Thank you
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29 July 2016 at 11:15 am #21588
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
We’ll have to re-treat. There are a few of us…..
Which genotype are you?

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
29 July 2016 at 11:21 am #21589
jeanmarc
- Topics: 2
- Replies: 9
- Total: 11
- Acolyte
@jeanmarc
I have génotype 4
Thank you for your answer
29 July 2016 at 11:48 am #21592
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
Did u svr12? Or u only test for svr24.
29 July 2016 at 11:53 am #21593
LondonGirl
- Topics: 16
- Replies: 1,348
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- Guardian Angel
@londongirl
Hi JM, So sorry to read this. There should be a few options for you I think, seeing as you just had the Twinvir.
Keep the faith
LG

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
29 July 2016 at 12:17 pm #21597
jeanmarc
- Topics: 2
- Replies: 9
- Total: 11
- Acolyte
@jeanmarc
I did only svr 12,wanted to sage money as I don’t have insurance covering this trèatment
29 July 2016 at 12:23 pm #21598
Fara
- Topics: 1
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- Guardian Angel
@fara
JM, Very sorry to hear your news. The newer medications options should be available soon. Good luck, It sounds like you have a good chance of clearing with the next treatment.

HCV since 35-40yrs., GT 1a , Dx 2004; VL 4-5 mil, F2-3
Tx sof/led started 3/4/16
4wks VL <15
9 weeks VL UND, ; Alt-15,Ast-13
16 weeks VL UND Alt-20, Ast-22;
EOT 24 wks UND
SVR 4 UND
SVR 12 UND, Alt.15, Ast. 17
SVR 24 UND
29 July 2016 at 12:37 pm #21599
Serg
- Topics: 4
- Replies: 66
- Total: 70
- Recovery Champion
@serg
jeanmarc wrote:

I finished my 3 monts treatment with twinvir 6 months ago and got a non detected result!
yesterday I got the result of my new viral 6 months after EOT and it’s detected again
So what I should do now ?
Thank you

Sorry to hear this. Firstly, I think it is better for you to retest PCR in different good laboratory. In my country (Russia), quality of lab analyses often is not best, and many “false positive” PCR results are registered on internet forums.

Probably infected in 1977
2005 – diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 – PegIFN/rib 48 weeks treatment, relapse
2016 – compensated F4, MELD 8-9, ALT 100-160
2018 – compensated F4, MELD 8, ALT 91
29 July 2016 at 1:16 pm #21601
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
jeanmarc wrote:

I did only svr 12,wanted to sage money as I don’t have insurance covering this trèatment

After eot, u only did the viral load (svr24) on 19 Jul right? (And skipped the svr12 test)
29 July 2016 at 1:21 pm #21603
jeanmarc
- Topics: 2
- Replies: 9
- Total: 11
- Acolyte
@jeanmarc
I did only svr 12,wanted to sage money as I don’t have insurance covering this trèatment

After eot, u only did the viral load (svr24) on 19 Jul right? (And skipped the svr12 test)

Yes
29 July 2016 at 1:23 pm #21604
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
Type 4 is very rare.

I hope you get retreated soon. The new meds have a better resistant profile
29 July 2016 at 3:51 pm #21616
coral
- Topics: 8
- Replies: 598
- Total: 606
- Guardian Angel
@coral
Hi JM. So sorry to hear your news. I have also relapsed after 24 weeks of treatment. I know it is incredibly disappointing but there are more treatment options now and in the pipeline. We need to take a breath and find out the best way to fight this again.
Coral
29 July 2016 at 4:23 pm #21618
mgalbrai
- Topics: 28
- Replies: 1,298
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- Guardian Angel
@mgalbrai
Coral & JM-
Sorry about the state of affairs. I imagine generic versions the new meds will be available shortly. They should work for you.
m

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
29 July 2016 at 10:23 pm #21630
Ariel
- Topics: 3
- Replies: 1,060
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- Guardian Angel
@ariel
Hi JM
I am sad to hear this news, I hope you can retreat asap there are many options on the horizon with DAAs as many have said
Sending empathy to you at this time
Ariel
30 July 2016 at 6:06 am #21653
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Hi Jeanmarc,

Sorry to hear that you appear to have relapsed as did I recently. As the others say, there are new medications becoming available but my advice would be that your best option is to consider arranging a Skype or telephone consultation with https://gp2u.com.au . They are up to date on latest treatments and will be able to provide sound advice regarding whether you should retest your viral load as a check and also probably to have a new genotype test to confirm correct treatment going forward.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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