Home Forums Main Forum FixHepC Admin Q & A Transmitting the virus after SVR12?

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  • #21582
    Peach
    • Topics: 1
    • Replies: 11
    • Total: 12
    • Acolyte
    • ★★
    @peach
    ”James-Freeman-facebook” wrote:

    Being a pragmatist what we want is cessation of disease progression and symptoms. The evidence to date suggests we do get that, however it’s been known since 2004 that you can still find traces of HCV at SVR. That’s the reason it gets called SVR rather than cure,

    http://www.ncbi.nlm.nih.gov/pubmed/15140984

    For practical purposes SVR is cure – at least for Interferon because we have long term follow up showing SVR is durable and the virus does not come back.

    http://www.sciencedirect.com/science/article/pii/S1413867010700702
    http://www.medscape.com/viewarticle/782532

    I spotted this in another thread here on the forum.

    Does this mean there’s a risk of transmitting the virus to others post SVR12 (+) until there is a way to eliminate these traces through future medical advances?

    If I am lucky enough to clear this time around I understand that I should be able to move on with my life and that, for all intents and purposes, the virus is gone and I can start to regain my health.

    I certainly won’t be offering my razor and toothbrush around to share with everyone, but it does make me sad to think that every time I get a cut or something I could be putting others at risk. The psychological burden of that is really difficult for me to handle.

    Also, what about sexual transmission in this case? Is there any cause for concern that the trace RNA could infect my long-term partner? Does this mean we’ll have to use a condom indefinitely (for example, risk from microscopic cuts or periods)?

    Is there any way one can be tested for trace RNA after achieving SVR? How long do they hang around for? The research papers seem to give conflicting results :dry:

    More articles:
    https://www.jci.org/articles/view/73104
    http://www.ncbi.nlm.nih.gov/pubmed/21040725
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608821/


    genotype 1a
    viral load 160,000
    age 29, F0, treatment naive, il28bcc
    unable to function due to chronic fatigue, joint/muscle pain, low immune system, depression, anxiety, skin issues, brain fog (etc) : (
    12 weeks daclatasvir/sofosbuvir started 11 march 2016 through pbs

    week 4 – alt 12
    week 12 – viral load undetected
    svr12 – NOT DETECTED!

    #21584
    Avatar photorohcvfighter
    • Guardian Angel
    • ★★★★★
    @rohcvfighter

    Hi Peach,

    That’s a very good question.
    The “traces of HCV” after SVR made someone working in the medical system tell me that I will never get rid of HCV, no matter what treatment I will take (with interferon or without it)…

    I am interested as well in finding out the answers to your question.

    Cheers
    RHF


    In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
    HCV kills more than 500000 people every year. HCV generic drugs work. Don’t become a statistic.
    By sharing this Youtube video you might save someone’s life!
    My TX: HEPCVIR-L[generic Harvoni]-India
    SVR52 achieved

    #21602
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    With an HCV viral load, ie pre treatment, sexual transmission with straight sex is extremely unlikely to cause infection. Anal sex is slightly more risky as blood blood contact can occur. Vaginas, penises and mouths have a relatively thick layer of cells that make blood blood contact rare and damage to the defences of both partners needs to be present at the same time.

    At SVR there is zero chance of causing infection.


    YMMV

    #21605
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Hi Peach
    I almost certainly contracted HCV in 1975(I got Hep B then) but wasn’t diagnosed until 2004.
    My partner at the time never got Hep B.
    My husband does not have HCV, nor do our children (born in 1990 and 1993)
    We unknowingly took risks.
    We used the same nail clippers very regularly ;)


    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    #21606
    Avatar photosabrecat
    • Guardian Angel
    • ★★★★★
    @sabrecat
    rohcvfighter wrote:

    Hi Peach,

    That’s a very good question.
    The “traces of HCV” after SVR made someone working in the medical system tell me that I will never get rid of HCV, no matter what treatment I will take (with interferon or without it)…

    I am interested as well in finding out the answers to your question.

    Cheers
    RHF

    Sounds really positive; did they explain how they arrived at this conclusion? Did they means the antibodies?

    Jeff

    #21613
    Avatar photorohcvfighter
    • Guardian Angel
    • ★★★★★
    @rohcvfighter

    Hi Jeff,

    I was getting such opinions from medical staff NOT being specialized in liver diseases.
    However, they looked at me like I was a poor and naive person, so any explanation would have been too much for my non-educated brain in medical sciences….. But, in my naivity I continue to hope that the generics killed already the HCV bastards ;-).

    P.s. please let’s not start a debate about such questionable remarks / advices originating from certain medical staff…. I am pretty sure many of us would have so much to tell :)


    In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
    HCV kills more than 500000 people every year. HCV generic drugs work. Don’t become a statistic.
    By sharing this Youtube video you might save someone’s life!
    My TX: HEPCVIR-L[generic Harvoni]-India
    SVR52 achieved

    #21617
    Avatar phototweakmax
    • Guardian Angel
    • ★★★★★
    @tweakmax

    I fathered two daughters even with a vl of 1.9 million. My wife is hcv free. With svr12, I am sure the chances of spreading=zero

    #21631
    Avatar photoAriel
    • Guardian Angel
    • ★★★★★
    @ariel

    Thank you Dr Freeman for your reply in this topic
    I asked this question myself of my public hospitals specialist and my treatment GP when I reached SVR12
    I have been assured there is zero way a non active, undetected virus can be transmitted, as there’s nothing to transmit; this is what I was told.
    I have two children and no vertical transmission ever occurred.
    I too have shared nail clippers etc as others here mention and nobody else has contracted hcv in my immediate family, and neither do I have it either now Thankyou to the generic medicines.
    Sure, there will be a marker to say we once had contact with the virus but it’s gone. (I am immunised for HepB and a marker shows that tells the doctor I have been immunised maybe HepC will just look like that now, seems logical)

    Anyway That’s my Drs explanation as well as I can relay it and it is just what dr J said here earlier
    So don’t worry it will be fine.
    Love from Ariel #love

    #21663
    Peach
    • Topics: 1
    • Replies: 11
    • Total: 12
    • Acolyte
    • ★★
    @peach
    ”James-Freeman-facebook” wrote:

    At SVR there is zero chance of causing infection.

    Thanks for clearing this up for me Dr Freeman, it’s music to my ears! #love <img style=illy:' />

    And thanks everyone for your comforting replies. Sorry for being a worry wart, I’ve been in a state of extreme anxiety lately at 8 weeks EOT and seem to be getting worked up about things,.. perhaps not thinking clearly? Just wanting to cover all my bases.

    Anyway, onwards and upwards!


    genotype 1a
    viral load 160,000
    age 29, F0, treatment naive, il28bcc
    unable to function due to chronic fatigue, joint/muscle pain, low immune system, depression, anxiety, skin issues, brain fog (etc) : (
    12 weeks daclatasvir/sofosbuvir started 11 march 2016 through pbs

    week 4 – alt 12
    week 12 – viral load undetected
    svr12 – NOT DETECTED!

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