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  • 27 December 2015 at 3:21 am #7352
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    From the University of Lyon:

    https://www.youtube.com/watch?v=fV-jhNQs_WE

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    27 December 2015 at 3:37 am #7354
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    Thanks Vororo, it’s a work of art.

    Almost meditative…

    27 December 2015 at 3:54 am #7356
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Thanks Vororo,

    I thought I knew a little about the subject previously but this taught me far more…….now I just need to read up on the 99% I still don’t get! :lol:

    Seriously though, a fascinating video that gave me a better understanding of the theory behind NS4B/NS5A inhibitors, et al.

    Thanks
    G

    Joy, as I was watching I thought it should have some early Pink Floyd as backing music. :)

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    27 December 2015 at 4:09 am #7358
    Avatar photopat1
    • Guardian Angel
    • ★★★★★
    @pat1

    Thankyou Vororo

    The video is just amazing – it gave me a visual insight into replication factorings that are so very complex
    I now ‘think’ I understand why the new DAA’s are such a scientific revelation

    gt 1a VL 6m
    F2/3 FibroScan – 9KPa in 2011 and 7KPa in 2015
    sof/dac 10 December for 12 weeks
    pre tx alt 85 ast 51
    4 wk alt 34 ast 31 UND <35
    8 wk alt 29 ast 32 UND <15
    12wk alt 25 ast 25 EOT 3.3.16
    SVR24 UND KPa5.3 F0 in normal range
    I am well
    .forever grateful to fixhepc

    27 December 2015 at 7:30 am #7366
    Avatar photopoodle
    • Guardian Angel
    • ★★★★★
    @poodle

    Thanks for that. I really appreciated the calming music while watching the little fellas party.!

    Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
    24weeks mesochem sof/led as unsure of fibrosis status.
    currently UND. No bad side effects
    Have svr12 … waiting for svr 24
    I now have SVR 36 weeks.

    28 December 2015 at 4:14 am #7402
    Joan
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    • Recovery Champion
    • ★★★★
    @joan

    Thanks for that… I didn’t understand much however its given me and insight as to how complex HCV is and the incredible research that has gone into the discovery of DAA’s not only for HepC but for other life threatening diseases. Science is truly remarkable.

    GT2B Diagnosed 1989
    Started Tx 6.Nov.2015
    F3 Fibroscan 17: April.2015
    Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
    Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015

    28 December 2015 at 5:17 am #7407
    Avatar photoArcher
    • Topics: 9
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    • Recovery Champion
    • ★★★★
    @archer

    It shows how NS5B, an RNA-dependent RNA polymerase, has been identified as the core of the replication complex – which possibly explains why sofosbuvir is a constant DAA throughout the treatments – working in tandem with various other inhibitors possibly selected through trial results on the basis of genotype. Of course not being educated in this field – my hypothesis could be total horse s—t. The video is superbly designed and medical training has moved to a whole new level with current technology.

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