Forum Replies Created

Viewing 15 posts - 1,636 through 1,650 (of 1,968 total)
  • Author
    Posts
  • in reply to: cheat sheet #7404
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello kenbasman,

    Essentially you don’t strictly require any monitoring unless you get unwell but:

    4/54 == 4 weeks post starting treatment

    FBC = Full Blood Count = CBC = Complete Blood Count
    Cr&E = Creatinine & Electrolytes = UEC = Urea Electrolytes Creatinine
    LFTs = Liver Function Tests like Bilirubin, ALP, AST, GGT, Albumin
    Hep C Viral Load = Quantitative HCV RNA

    The 4 week test typically shows (80%) viral load zero and proves the meds are valid and working.

    If you want an early proof your AST will fall rapidly back to normal

    Once viral load is zero there is really not a lot of need for further monitoring (unless on Ribavirin)

    The 12 weeks versus 24 weeks length decision is based on Fibrosis. If you have cirrhosis (F4, > 14 kPa, Hepascore > 0.5) then you need 24 weeks.

    Next test after viral load zero can be SVR4 or SVR12 – Viral load 4 or 12 weeks post finishing treatment, and a VL=0 at 4 weeks = 96% chance of cure, and at 12 weeks 99% chance.


    YMMV

    in reply to: Hetero … Sof, Sof/Led Combo #7398
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Bull Pharmachem has a free page on Indiamart and the domain was registered on the 4th November 2015.

    https://who.is/whois/bullpharmachem

    The domain registrant address is in Australia but the +45 phone number is Denmark.

    At best it’s a new single operator trying to make a dollar. At worst you may not receive what you have paid for.

    Proceed with caution.


    YMMV

    in reply to: Dental work, local anesthesia, xray on sof/led #7397
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes, there is no problem with this


    YMMV

    in reply to: Fibrosis/Cirrhosis info corner #7396
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Hazel,

    It will be the Riba making you feel bad. If you read http://fixhepc.com/forum/gt3/369-gt3-high-svr-rates-with-daclatasvir.html you will find an n=468 study (the biggest Sof+Dac study to date) that failed to show any benefit in an subgroup of F3 & F4 GT3 patients by taking Ribavirin. If you are doing 24 weeks this suggests that your results will be equal or better – Riba than + Riba.

    Ribavirin has a 1/2 life of 12 days so when you stop it takes 12 days to fall to 1/2 the starting level, 24 days to fall to 1/4, 36 days to fall to 1/8.

    I understand why intuitively it might seem “more is better” (and therefore + Riba is better) but the evidence suggests that is not the case.


    YMMV

    in reply to: Is a good idea to take some probiotics on sof/led #7375
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Do these meds affect the flora of intestine?

    No.

    Do they kill the good bacteria?

    No, they don’t kill any bacteria.

    Can we take probiotics while on treatment?

    Yes.


    YMMV

    in reply to: Emilio’s Place #7370
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Em

    Glad you had a lovely Xmas with your family. I finish mid February as well however only 12 weeks for me. I did read where you were going to take an extra 6 weeks…is this something new or more a personal choice? Just curious as I am 1b as well.

    Cheers Lynne


    YMMV

    in reply to: Drinking alcohol #7365
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I have acquired a taste for Coopers ultra light beer which had 0.05% alcohol (don’t drink it a lot though) and also Holstens non-alcoholic beer….sounds gross but isn’t a bad drop once you get used to it. I miss my Bacardi though :(


    YMMV

    in reply to: Residual Solvents in Certificate of Analysis #7347
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I doubt any manufacturer gets all traces removed to the point of 0.0

    Absolutely correct. It is possible to get to purity values of 99, 99.9, 99.99, 99.999 but each extra “9” you want increases the price by a factor of about 9!

    HPLC can deliver near 100% purity but does not work at scale, so other more time/cost efficient methods of purification are used.

    With residual solvents near enough is good enough. They are normal, expected, and will have no impact on efficacy.


    YMMV

    in reply to: 2B HERE #7308
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Joan When you say Viral load 0…did that actually show “0” on your test or did it just read “undetected”…I admit I am confused on that point…although my test at four week was HCV undetected so assume that means no Hep C in my system anymore.

    So glad you are doing so well. My sleep is still not so good, waking early all the time but generally I feel so much better.


    YMMV

    in reply to: isaing4 Twinvir story #7278
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Just to confirm what others have already correctly told you.

    4/52 is doctor code for 4 weeks

    8/52 would be 8 weeks


    YMMV

    in reply to: Dan’s Twinvir story #7277
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    You should see a doctor about the ankle swelling.

    I have a handful of patients who have developed fluid retention on treatment initiation.

    It can be treated with diuretics but should not be ignored. It can progress to ascites.

    Please check in with a doctor.


    YMMV

    in reply to: All that valuable Data that goes down the plughole #7275
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    At the heart of the REDEMPTION eTrials is a simple online data collection portal.

    Because we are dealing with generics the data gathered is focussed on the efficacy of the medications themselves.

    The size will allow answering the questions we need answers to.


    YMMV

    in reply to: blood tests required during treatment – Sofo/Dac? #7270
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    That’s undetected.

    The < 15 and < log 1.18 (1.2) are not printed by many labs when it is undetected. We do see <15 Detected Which means too low to count but still present. Yours is too low to count AND can't see any. It is zero.


    YMMV

    in reply to: blood tests required during treatment – Sofo/Dac? #7268
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi 2b,

    There are several different ways results are reported.

    If a QUALITATIVE HCV RNA is requested the what you get back is a simple DETECTED/UNDETECTED

    If a QUANTITATIVE HVC RNA is requested then the results may look like

    < 15 Detected <15 Undetected N (where the <15 would go) N=HCV RNA not detected Where there is a <15 the is also often a < log 1.2 reported. If you post the data bits of your results I will tell you what it means. If it says undetected somewhere that means we can't see it (as well as it being <15)


    YMMV

    in reply to: blood tests required during treatment – Sofo/Dac? #7264
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I would be interested in this too…my test just had HCV undectable…….not sure where to look on the tests for VL0.


    YMMV

Viewing 15 posts - 1,636 through 1,650 (of 1,968 total)