At SVR24 we are 99.99% certain there will be no relapse. The 1:10,000 who do relapse are suspected to be reinfections, rather than true late relapse cases.

This makes sense when you think about it. The incubation period for Hep C is 14-180 days. It only takes 1 week for the drugs to wash out of your body (1/128 level) which is below the therapeutic level. By 2 weeks there is only 1/16,348 the level on treatment. So after this time the virus (if there was any left) has, by SVR24 had a full 22 weeks to grow back unimpeded by the effect of the drugs.

It’s logical that if it has not grown back by this stage then the reason is there was nothing left to grow back.

Hi Chris,

Let’s see how you are tomorrow. If you’re worse some antibiotics would be a reasonable idea.

We can sort that out easily enough.

Hi Chris,

Welcome to the forum. Normal doses of paracetamol or ibuprofen are both fine on DAA treatment.

There is both a flu-like illness (but without the cough and mucus) and a runny nose/sore throat type thing that can happen with DAA treatment.

From what you describe I’d be agreeing with you that you do have something more than just side effects.

What colour is the mucus you’re coughing up?
Do you take any other medications?
Any other medical problems besides the Hep C?

Hello tototo,

With Harvoni 8 weeks is not as good as 12 weeks.

With Mavyret 8 weeks is as good as 12 weeks Harvoni.

It’s possible your stomach bloating and skin itch relate to the Mavyret as rashes and stomach upset are the commonest side effects of any drugs.

I would expect that to settle down when you finish (today!) and that you will achieve SVR12.

It is very hard to transmit Hep C without blood to blood contact, so a mother giving it to a child after the bloody events of birth is very rare.

The easiest thing for peace of mind is for you to get treated and SVR12. Check your son one last time at that time. If no antibodies then you have been non-infectious for well over the incubation time and there is no chance your son will come up positive.

Hello MAGA, yes that elevated CK confirms it was related to muscle damage from exercise and the falling AST/ALT are reassuring.

What sort of exercise do you do?

If it is weights you are probably pushing the envelope a bit hard

If it’s endurance then you’re probably not hydrating adequately and overheating

For the blood sugar

<100 is normal
>200 is definitely diabetic

And between 100-200 is something of a gray area. If you have a look here

http://www.diabetes.org/are-you-at-risk/prediabetes

You will see <100 fasting and <140 following the glucose challenge - so one lab is using the 100 for fasting, the other the 140 for not fasting.

Hi vitrus,

Thanks for your valuable input.

MAGA is a patient of mine who should (theoretically) be straightforward. Reassuringly he feels well, despite the AST/ALT rise.

GT2, low fibrosis (0.7 Fib-4 and 0.559 APRI), Hep B core Ab negative, young(ish) and fit.

We’re getting follow up bloods done to check the trendline on the enzymes and INR to check liver synthetic capacity. Bilirubin has fallen rather than risen.

He takes quite a lot of supplements and exercises extensively so checking CK as the enzymes could be exercise related and stopping the supplements, one of which has a lot of green tea extract (and this has been known to cause liver toxicity problems).

Exercise wise we have seen enzyme rises with kaju https://fixhepc.com/forum/new-to-forum/1748-need-advise-for-gt4-treatment.html?start=45#26349 where the ALT/AST rise appeared to relate to heavy exercise.

I have also seen an acute CMV reactivation mid-treatment but this was associated with significant unwellness and was similar (clinically) to Hep B reactivation.

Anyway we are onto it and are considering if it is a DAA related drug reaction. With any luck the new bloods will show reduced AST/ALT and we can take an expectant approach.