Forum Replies Created

Viewing 15 posts - 541 through 555 (of 1,968 total)
  • Author
    Posts
  • in reply to: HCV people should take control over their own life #27448
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Have you ever heard of a government program that worked, reached it’s goals and then was dismantled?

    Fair point, but there are two that I recall, both a long time ago now…

    https://en.m.wikipedia.org/wiki/Lend-Lease

    And this one one of American awesomeness…

    https://m.youtube.com/watch?v=g25G1M4EXrQ


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27438
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    We say 2 weeks because it can take that long, and sometimes longer. 2 days does sometimes happen…. Clearly the stars are coming into alignment for you.


    YMMV

    in reply to: Extra-hepatic Manifestations #27428
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Here is an in-depth analysis of the extrahepatic manifestations:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735500/


    YMMV

    in reply to: Fertility #27427
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello MWILLIAMS,

    Being a man, not personally, but I have a number of patients who have.

    There is no impact on fertility from the treatment, however getting pregnant and breastfeeding on the treatment is not recommended. It is “probably safe” but nobody wants to test that theory. Really the only drugs that are classified completely safe in pregnancy pre-date thalidomide – since then nobody has wanted to test and see…


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27426
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Harvoni has the best track record of any drug in GT1 with multiple sources of independent validation.

    Sof/Vel is new and there are absorption issues around the velpatasvir in some patients. Because it’s new, most of the data is company data and the Harvoni data (from the company) was a little on the optimistic side.

    We have used quite a lot of Sof/Dac in GT1 and I am aware of a large independent study about to be published about it, but because of the originator price being north of $100k there is less in the public domain.

    Any of these are good, and the number of failures so small it’s hard to pick a clear winner.


    YMMV

    in reply to: Quote of the day #27424
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    “A human being should be able to: change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, co-operate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently and die gallantly. Specialization is for insects” RobertHeinlein

    Does taking on Big Pharma with generics count under “plan an invasion” ?

    Here’s one of my not-a-sonnet sonnets

    The Path We Choose

    Do not shed a tear for me
    For I would not for you
    Instead just drink a beer for me
    And know well that I knew

    Dreams of flight do not come free
    There comes attached a price
    And we do not do it blindly
    We know we roll the dice

    Before you sail into the sky
    A sky slow to forgive
    Ask am I, afraid to die?
    Or just afraid to live?

    So if you try, to reason why
    When fate can seem unjust
    We take these risks, not to escape life
    But to stop life escaping us


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27423
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Sof/Dac is as good as Sof/Vel and more reliably absorbed.

    While there is nothing really wrong with doing a bit extra for insurance you are looking at a baseline 95-96% cure rate with 12 weeks.

    If you are undetected at 4 weeks after starting the tablets then you are on track and should probably just sit tight.

    If mentally it’s going to bug you severely then it’s not completely insane to do a bit longer, either with the same medication, or a pangenotypic like Sof/Dac or Sof/Vel.


    YMMV

    in reply to: Extra-hepatic Manifestations #27414
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Tigerfan,

    The best way for a patient with HCV to reduce their portal pressures is to treat the HCV.

    In the liver HCV causes both fibrosis and necroinflammation. You could thing of the necroinflammation as like blowing up balloons in a fibrous 3D mesh. This blocks the veins. If you treat the HCV the necroinflammation subsides so the balloons shrink and even though the fibrosis persists (it regresses slowly) there is a near instant improvement in liver stiffness measurements which reflect this.

    As far as your BP goes this does not relate to you liver. Your kidneys control it.

    The reason your BP is lower post exercise is that you open up the vascular beds in your muscles, this reduces vascular resistance, and in turn the BP falls. As the vascular beds close down your peripheral resistance rises and your BP goes up.

    We know that patients with a BP persistently over 160/90 die quicker from heart disease and stroke. If this is you then you should:

    1) As a 1 off get check for renal artery stenosis (Ultrasound)
    2) Suck it up and take an ACE inhibitor or ACE Receptor Blocker (ARB) – both of these will drop you BP without impacting on your athletic performance.

    95% of all hypertension (high BP) is called “essential” which means we don’t know what causes it. We do however know how to fix it, and we also know that fixing it translates into less heart attacks and strokes.


    YMMV

    in reply to: Exercise during treatment #27413
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Tigerfan,

    You’re welcome to ask whatever comes to mind. It’s likely you’re not the only person wondering!

    There is nothing like practical experience when it comes to answering questions. There is a lot of that floating around here on the forum.


    YMMV

    in reply to: Exercise during treatment #27407
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Some people do report a sort of high related to the pills. It’s hard to know if it’s just “less virus = feeling better” or a “lifting of the brain fog so the world seems brighter” or what…

    Anyway, no, it does not matter.

    The main thing with Epclusa is to take it with food. It needs food (fatty food) to help it get absorbed optimally. Your blood pH barely changes when you are running lactic acidosis and has no impact on the absorption of the medications.


    YMMV

    in reply to: Alcohol #27399
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello user123, In the context of low fibrosis and with the bulk of the treatment job done in the first few weeks abstinence is unlikely to benefit either your overall liver health or the success of the treatment.


    YMMV

    in reply to: RNA came back positive and going to GP in 2 days #27396
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Sorry about that.

    Our CC processor doesn’t process Amex.

    Wire transfer works fine, but so does Visa or Mastercard


    YMMV

    in reply to: Determining Originality of Medication #27395
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Yugen88,

    The only way to know with 100% certainty is to subject at least 1 tablet, selected at random to qNMR or HPLC-MS. These are both high cost laboratory instruments. We do this on request.

    We have a section on supply chain integrity which is really important with getting things online. https://fixhepc.com/supply-chain-integrity.html

    Mylan make good medication. The trick is making sure Mylan made it.

    If you want to post some photos I’ll compare them to a sample box we have in the safe.


    YMMV

    in reply to: стоит продолжать пвт #27370
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Для кого-то с GT1b, у которого неудачный режим Sofosbuvir в два раза идеальное лечение:

    Glecaprevir / Pibrentasvir (Mavyret) + Sofosbuvir +/- Ribavirin

    Далее – Vosevii

    Sofosbuvir/Velpatasvir/Voxilaprevir

    Еще одна хорошая альтернатива (то, что я сейчас использую для всех отказов GT1)

    Paritaprevir/ritonovir/Ombitasvir (Viekira or Qurevo) + Sofosbuvir +/- Ribavirin

    Бедной альтернативой является

    Sofosbuvir/Velpatasvir + Ribavirin

    В настоящее время доступны только последние 2 варианта. Viekira продается как Qurevo в Египте и является общей ценой уровня.


    YMMV

    in reply to: стоит продолжать пвт #27369
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Для кого-то с GT1b, у которого неудачный режим Sofosbuvir в два раза идеальное лечение:

    Glecaprevir / Pibrentasvir (Mavyret) + Sofosbuvir +/- Ribavirin

    Далее – Vosevii

    Sofosbuvir/Velpatasvir/Voxilaprevir

    Еще одна хорошая альтернатива (то, что я сейчас использую для всех отказов GT1)

    Paritaprevir/ritonovir/Ombitasvir (Viekira or Qurevo) + Sofosbuvir +/- Ribavirin

    Бедной альтернативой является

    Sofosbuvir/Velpatasvir + Ribavirin

    В настоящее время доступны только последние 2 варианта. Viekira продается как Qurevo в Египте и является общей ценой уровня.


    YMMV

Viewing 15 posts - 541 through 555 (of 1,968 total)