Hello Smp123,

You’ve been given some good pointers already. This is a good thread discussing Daclatasvir

https://fixhepc.com/support-forum/drug-interactions/611-cyp3a4-inhibitors-and-daclatasvir-fruits.html

Taurine is in red bull and other energy drinks and some body building supplements. We got it added to the literature because we saw people failing on treatment because of it.

You will find the official manufacturers detailed instructions here: https://fixhepc.com/medication-information.html

There is both the simple patient info version and the complicated doctor one.

That is funny as hell!

Hi Erica,

Thanks for the update on how it’s going and your kind words. Jan is fabulous!

Fingers crossed for SVR.

Hi Nitro,

Welcome. I can understand your frustration and you’re right that things in the US need to change.

You may like this:

[video]https://www.youtube.com/watch?v=Pyo2KJbKGgU[/video]

Hello kaju,

Viral loads fluctuate.

The average is 2-3 million.

There is no correlation between viral load and severity of disease.

There is no correlation between viral load and symptoms and

Cure rate is the same for patients with 10 million and 10 thousand viral loads.

Yes, you have Hep C and treating it is a good idea.

Any viral load over undetected is too much…

So with Hep C the screening test is for the HCV Antibody. This is positive in 100% of people exposed and infected with Hep C.

Of that 100% about 1 in 4 or 25% have immune systems capable of clearing the virus without help. The remaining 75% can not get rid of the virus so have what we call chronic Hep C.

To differentiate between people who have cured themselves we look for the actual virus, to be specific the RNA genetic code at the core of the live virus.

We do this using PCR (Polymerase Chain Reaction) which is a technique to turn a small quantity of DNA or RNA (the genetic code of life) into a big quantity. We need to amplify the quantity like this to give us enough of this stuff to count.

The test that does this is the HCV PCR RNA test. This is negative in patients who have cleared the virus naturally (or with the help of drugs) and it is positive in patients who have chronic Hep C.

So, for you, good news would be A ) Normal liver functions and B ) a negative HCV PCR RNA.

Notice the A. The usual reason people get tested for Hep C is because they have abnormal liver functions. If you have abnormal liver functions and a negative HCV PCR RNA then the cause is not Hep C because you don’t have Hep C.

Here is the big list of other things that cause liver problems: https://www.mayoclinic.org/symptoms/elevated-liver-enzymes/basics/definition/sym-20050830

Hi 40-odd,

Retreatment is a little more tricky that first-time treatment, but you are in the easier group ie those people who did not clear on 8 weeks Harvoni might well have on 12 weeks.

From what you’ve written you were undetected at SVR12 – 12 weeks after finishing the tablets. It is very unusual to relapse (as in 2/779 or 0.3%) at this stage. This could be interpreted as “gosh we were close” or maybe you have been reinfected.

What’s required is a decent length discussion with somebody like me who knows a bit about both the treatment and retreatment. I have about 3000 patients finished or still on treatment and, failure rates being what they are, have retreated over 100.

Success rates for retreatment are very good (still over 90%) but the precise choice depends on lots of things specific to you.

You can book an appointment with me online (so we see each other by video) at https://gp2u.com.au/