Can anyone tell me if it’s normal to feel VERY TIRED from the drugs?

My observations are:

1) The closer people are to the edge the longer it takes to drag them back
2) The usual 1 week “a bit under the weather” on treatment initiation is more like 2-4 weeks in cirrhotics
3) Cirrhotic viral loads, enzymes and bilirubin take longer to come good, and platelets take even longer

The reality for some people is that treatment arrives too late to drag things back, and transplantation will still be required.

I have one patient like that. He was in ICU when we started treating him 6 months ago, and has no viral load, but his liver was/is so shot he’s now on the transplant list. Without generics he would have been on the casualty list.

So enough results are in, and out of embargo so now I can say what I was dying to say at the time, well actually…..

Generic Sofosbuvir + Ledipasvir delivers damn good SVR rates and we repeated a trial Professor Gane did (26/26) with Sof+Led+Riba in GT3 and got 13/13 = 100% SVR – please don’t get excited this was in treatment naive low fibrosis GT3 only and the +Riba was essential.

Here is the data: http://fixhepc.com/forum/media-news/914-easl-slides-94-4-svr4-overall.html

Although we are surrounded by the cone of silence maybe if we all shout really loud somebody will hear it!

Something like….

In the time it took to give this presentation another 15 of our fellow citizens perished from a disease we have the power to cure.

We have the power to FixHepC.

My question to you, the audience, is do we have the will power? The will power to think global, but act local, and see cure deployed on a mass scale?

…Or would we rather blindly protect patent rights at the expense of patient lives?

Generics work. We’ve already seen them work for HIV and now we can see that they work just as well for HCV, so let’s deploy them and wipe Hepatitis C off the face of the planet…. just like we’ve done with smallpox and polio

Hi Joy Your link is “currently under maintenance” so I will have to read it later..

4 hours after you take your last dose you can take all the PPIs you like.

At this point you will have absorbed all the medication so….

Since only 1 out of 4 was potentially fatal, I figured the odds were acceptable.

You have to admit in retrospect, it was a pretty big leap of faith….

Plus I had someone telling me they would give them to their mother…..

The “mum” test remains my moral true north.

I confess I took some of the API myself before I sent it to my patient zero. The tests looked good and it didn’t kill me so I figured it should be ok.