Forum Replies Created
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Oh, and my compliments to Hepatitis Foundation NZ. A very well presented, informative and easy to read magazine.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
The cynic in me says that it’s a great way to publicly claim to be helping a whole nation while simultaneously getting research data for not too many $$$ and no significant impact on Gilead’s commercial markets.
But best wishes to the Icelandic heppers for their luck.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Hamilton,
Like you I’m also doing the hard yards with the Riba. As you say past failure, plus my liver is made of old boot leather apparently.
Well, after a 3 week wait due to the hols I got my 4wk RNA result this morning. I have Hep C….well, who’d of thunk it?
Apparently the lab only ran the basic qualitative for detected/undetected so now need to rerun with quantitative to see what level I reached…..sigh!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sonix,
Great to hear you are noting some improvements.
Your comments about the heat are interesting, I noticed I handled it a lot better than I had pretreatment. Still bloody hot but I wasn’t struggling like I have for the last couple of years. Although I am 4 weeks further into treatment than you.
Best wishes for your 4 week results.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sonix,
Joomla/kunena
A quick search shows others have similar issues and I suspect FixHepC have other priorities than enhancing user’s emoji experiences.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
sonix wrote:
Some of the comments on that page reveal the ignorance of the public re HCV……
……..in Australia every news media has carried stories of the new DAAs and recent government scheme.True sonix,
Having recently come out and started telling people of my situation, I am astounded at the level of ignorance that does still exist in the community. Someone I recently told who I consider well educated, with an enquiring mind commented that they had seen the announcement on the news but hadn’t taken much notice of the detail and during further discussion that they were aware of the blood to blood contact situation “but could I catch it by, say….sharing a water bottle with you?”
And they have certainly not been alone in that level of understanding. Most people are amazed when I point out that about 180M or one in forty people worldwide have HCV. All basically driven by the stigma of having it and the associated taboos around talking about it.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Yay! Finally got them LondonGirl! When will you start?
“Well,” said Pooh, “what I like best,” and then he had to stop and think. Because although Eating Honey was a very good thing to do, there was a moment just before you began to eat it which was better than when you were, but he didn’t know what it was called.”
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
:
“The HCV turnover rate can be quite high with replication ranging between 1010 to 1012 virions per day, and a predicted viral half-life of 2 to 3 hours.”http://www.medsci.org/v03p0047.htm
Or 100 to 10,000 Billion per day. So it may not take very long at all to get back to high levels depending on how well your immune system is fighting it.
Sorry to hear of another example of ‘care and support‘ as provided by a few who utilise the stigma of this virus to inflict their morality on others!!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Ahm s’praised Oor Wullie wasnae eggsilde fae no swalleyin!
Were all those results from the same lab? They seem to jump around a lot. Mine moved from month to month but recently the ALT/AST were fairly steady over a year or so.
I have old tests where they checked my lipase but seems unremarkable and doesn’t get checked currently.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Double post
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sonix,
While there are certainly arguments around advisability of statins as a long term preventative measure for cardiac incidents vs any potential side effects, in this case I believe we are talking about using them short term during treatment and maybe out to SVR for their intended purpose of reducing high cholesterol levels and thus making HCV transport and replication less efficient. Also as Dr James noted, for gt 1 and 2 with low F score, etc there may be little advantage. However, for a gt3 like myself where I have <90% chance of SVR every little leg up helps so I plan to investigate it further
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Undetected means they couldn’t detect any viral RNA in the blood samples they took. However, there could still be a few stragglers “hiding” somewhere in your body, most likely in the liver. This is one of the reasons those with cirrhosis must undergo longer or stronger or both, treatments. The theory is that the scar tissue of cirrhosis creates a barricade of sorts that the medications have more difficulty penetrating which some of the virions can hide behind and they come back out and start replicating again once the meds have stopped. So you medicate for longer to ensure that the meds “soak” right in and reach and kill those.
Here is data Dr James provided on likelihood of cure based on SVR times. So at 6 months (SVR24) post treatment UND means greater than 99% chance that it is gone for good.
http://fixhepc.com/forum/experts-corner/364-viral-load-quantitative-vs-qualitative.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Bristol-Myers Squibb who invented Daclatasvir recommended against Grapefuit and Seville Oranges and marmalade containing either during the trials I participated in. The instruction was that Navels and Valencias would be fine. They made no mention of limes or lemons so presumably they are not an issue. I haven’t read Gilead’s instructions about meals but the rest of it relates to them being suitable for use with prescription antacid type products at up to certain levels for control of gastric reflux.
Otherwise avoid ‘potent’ inhibitors and inducers and if in doubt and you eat “a lot” of something like soy or miso or really anything else that you have concerns about it is probably best to at least reduce it particularly within a few hours of your medication, leave it out, or seek advice from above two companies or your specialist. Keep in mind that everyone who takes these medications reports finding their liver functions improving considerably and very quickly as well as the huge majority clearing the virus. So you may want to consider whether it is wise during treatment to use other additional methods of improving liver function which won’t clear the virus but could effect the medication.
And check the drug interaction charts which also contain the “big” known food and herb items like grapefruit and St Johns Wort.
Hope that helps.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Well yes, but all that exercise just makes me even hungrier. I am feeling fitter though.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Don’t know about the Led interactions as I just checked Dac which I need.
My understanding with Sof, Led and Dac is that you want to get them into the bloodstream and from there to the liver as quickly as possible so either on their own or with a light, low fat, easily digestible meal is best. This is why I take mine prebreakfast allowing time for them to be absorbed. I also take Ribavirin which should be taken with food and preferably with fat to better absorb it. So I have those after breakfast which is cereal and full fat milk (that’s new!) and again after the evening meal which I make sure has some fat either in the meal or as an extra. But that is just for Riba.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
