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2 July 2016 at 9:13 am in reply to: GT2 Honks About Generic Sofosbuvir +Daclatasvir (SOF + DCV) #20307
I took my last generic SOF + DCV tablets today. I’ll start my journey along the road to SVR tomorrow. I’m hoping for a trouble free trip, with plans to purr along at cruising speed, and take plenty of rest stops along the way. If the next 3 months go by as quick as the last 3 months, I’ll be as happy as a teenager in a souped-up VW Beetle with a Porsche badge glued to its boot & bonnet (trunk & hood).
The last 2 weeks of my treatment have been a bit of a bumpy ride. I didn’t do any exercise during the second last week, and started to feel worse after 3 days. After a week of no exercise, I was lethargic, started getting headaches, and was feeling flat as a tack in general. I thought resting would reinvigorate me, but it had the opposite effect. Thankfully, the funny feeling (tightness) in my chest/heart went away during this time, which was a relief, but my fasting blood glucose increased back up to the high 6s.
I started exercising again during the last week, at random times whenever I had the energy, and started to feel better again after a couple of days. The headaches stopped. I put this down to drinking more water while exercising. It’s an easy way to make sure you drink plenty of water during winter. Now I’m feeling a lot better. The moral of the story is to do regular moderate exercise, but don’t overdo it.
Over the 12 weeks of treatment I have lost just over 7kg, mainly around my mid drift. I’m very happy about not having a “beer gut” anymore. The upside is the “’We aim to please, you aim too please” sign in the toilet is no longer needed, now that I’ve got line of sight. The downside is, after dinner while lying back in my recliner watching the nightly news, I no longer have a convenient spot to rest my coffee mug.
Over the next 4 weeks, I will slowly increase my exercise routine and closely monitor my fasting blood glucose. If it has not significantly improved during this time, I will get the necessary test done to obtain a prescription for metformin. I may simply be predisposed to type 2 diabetes (T2D) and HCV may have brought my T2D progression forward by a decade or two. Time will tell.
The wealth of information on this forum has answered all my questions that I ever have had about HCV and its treatment, questions that I would never have had time to ask, or even had thought about asking, while having a face to face consultation with a medical professional. The daily input by Dr Freeman, the FixHepC team, the moderators, and other forum members sharing their experiences, helped to keep my treatment on track, kept me updated on HCV treatment developments, and gave me solace that I’m not the only one going through this. Thanks to you all.
I recommend to any HCV sufferer, who has had trouble accessing HCV treatment or has failed past treatment, to join this forum and start their generic HCV treatment. It’ll probably turn out to be the best decision about your health that you have ever made. Do yourself a favour, and hop to it.
As the sun slowly goes down on my last day of treatment, I’ll leave you with the below sunset at Cable Beach, Western Australia. I have a near identical photo like this of my silhouette while I was fishing at Cable Beach as the sun kissed the Indian Ocean. I’ll dig it up and post it for my SVR12, if I get there, as it reminds me of good times in the past and gives me hope of good times in the future.
Wishing everyone HCV RNA Undies from Down Under
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Price
You may think that the stigma of having HCV is funny, or non-existent, but if you had HCV and had experienced the stigma, you wouldn’t be laughing so hard. I suggest that you read some of the numerous personal stories of prejudice experienced by us HCV sufferers, shared on this forum, to gain some empathy.
Your comments surprise me to say the least, especially coming from someone said to be employed in the medical profession.
A disappointed GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂hmy:
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂29 June 2016 at 7:43 am in reply to: FDA approves Velpatasvir plus Sofosbuvir single tablet Epclusa #20095The Business Wire link quotes Gilead’s CEO as saying:
“Today’s approval represents a significant advance for patients with HCV genotypes 2 and 3, who previously required more complex and costly regimens,” said John Milligan, Ph.D., President and Chief Executive Officer of Gilead. “As the first and only pan-genotypic cure for hepatitis C, Epclusa has the potential to eliminate the need for genotype testing, which can be a barrier to treatment in certain resource-constrained settings. We look forward to making Epclusa available to patients around the world as quickly as possible.” See:
Generic Darvoni (SOF 400mg + DCV 60mg) was the first and only pan-genotypic cure for HCV(until now), see:
https://fixhepc.com/forum/media-news/1053-darvoni-story.html
Therefore, Epclusa (SOF + VEL) is the second pan-genotypic cure … the first to be FDA approved … only because Gilead (SOF) and Bristol-Myres Squibb (DCV) didn’t want to work together and share profits. It’s all about trying to corner the market with a one pill cure all. In other words, it’s all about maximising profits, NOT about maximising the number of HCV sufferers being cured.
Epclusa may be an advancement for difficult to cure GT3s, however, it is NOT a significant advancement for GT2s who have a very high clearance rate taking Generic SOF + DCV on this forum. All you need is Darvoni for approximately USD700 + shipping & handling for a 12 week treatment. See:
Knowledge is power. Knowledge shared is power multiplied.”
Robert NoyceCheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂This says it all.
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Michael
Love your attitude to your latest diagnosis of CLL … it’s just another hurdle you’ll jump over.
Good luck tomorrow. Keep busy, and hopefully the next 12 days will fly by and we will all be celebrating with you on your SVR 12 result.
I’ve got my fingers crossed for you.
Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Dac
Some tried and tested home remedies for diarrhoea include yoghurt with live probiotics, ginger, bananas and apple cider vinegar. Try some or all to see which ones help you.
Despite the side effects, being UNDETECTED at 12 weeks is something to celebrate.
Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Dac
Good to hear that you are still UNDETECTED at 12 weeks.
I would be hesitant to drop the Rib considering the Hepcivir L + Rib combination is working so well.
I’m not a medical professional, so my opinion is merely a lay person using logic.
Sorry to hear about your dose of diarrhoea and the itchy rash. I would be seeking out remedies for those instead.
A discussion of remedies for rashes can be found here:
http://fixhepc.com/forum/end-of-treatment-eot/730-5-months-post-harvoni-horrible-rash.html?limitstart=0http://fixhepc.com/forum/end-of-treatment-eot/669-lynne-s-end-of-treatment.html?start=15#14690
I’m sure others can suggest remedies for the diarrhoea.
Ribavirin has a long list of side effects, however, try to look at it as short-term pain for a long-term gain.
Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂[video]http://https://www.youtube.com/watch?v=LZFO8pXuRTk[/video]
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂26 June 2016 at 8:13 am in reply to: BBC Newsnight – mostly talk about media representation & greed #19950
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂[video]http://https://www.youtube.com/watch?v=hnTmBjk-M0c[/video]
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂[video]http://https://www.youtube.com/watch?v=d-diB65scQU[/video]
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂 -
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