Forum Replies Created
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Welcome in the SVR24 club, with so many members!
Congratulations Greedfighter ! Cured !
All the best and good health!
I am so happy for you! Well done!
Welcome in the SVR12 club, with so many members!
All the best and good health!Congratulations ! Party time!
I am sooo happy for you!
Ma bucur muuult pentru tine! Congratulations! Well done!
Felicitari! Bravo!
Hi coral,
I am happy for you that you started second treatment. Already more than a month …
I’m sure that this time you will succeed!I wish you all the best and good health!
Hi LondonGirl,
I’m fine, thank you! I am eternally grateful for life without hepatitis C.I’m sure you will succeed!
Of course rohcvfighter, the system does nothing (or almost nothing, only 5000 new therapies for patients with advanced disease F4) for a very obvious reason – money.
Generics in the Romanian NHS are not discussed yet. Only originals. For Viekira pak Romanian NHS has achieved a very good price 18,000 euros, less than interferon + ribavirin 30,000 euros. Financial interests are clear. The pharmaceutical industry is powerful and will not give up easily on the” hen with golden eggs”.
Fortunately more and more doctors in Romania are informed about the efficacy of generics and follow patients who have decided to heal now not in an uncertain future.
From the medical point of view the CNAS – Romanian NHS – they are covered. It offers interferon + ribavirin, if you’re in the disease stage F0 to F3. They are not interested in the chance of cure 50% or that side effects can be significant.
It’s great that there are generic for hep C. I’m happy for all those who chose this risky way in the beginning and now have succeeded or will succeed to get rid of this disease.
But I am also glad for those who choose the way to fight the system legally. Romanian legal system gave justice. I hope that the example of this patient to be followed by others.
Yes beaches, the important thing is that they did a legal precedent. It will be easier for those who follow.
rohcvfighter wrote:there are only some days left until I will know what I already feel.
In the last weeks I felt very well, no more that discomfort in the right part of the abdomen and …. quite happy and optimist.
Apart from the physical improved condition, it is amazing to see how much the psihic condition changed in good: having trust in the future
Hi rohcvfighter,
I’m glad you feel so well physically and mentally. A little more and you will have good news clearly written on paper.I wait for you in the club SVR12 with more and more members!
Hi LG,
I know what it’s like to wait! Ups and downs!
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But there’s so little until you have a written confirmation in black and white. ALT is excellent, a good predictor!
I wish you to be a member of the club SVR12 with more and more members.
All the best and good health!
Dan wrote:Hi.
Got my results for SVR 24. UNDETECTED!!!!!!!
Live function is normal.It was a long journey
I am happy for you Dan!
Congratulations for SVR24, you are cured! We made it!
What journey for every hep C patient treated with those miraculous new medicines.
I wish you all to be cured and be members of the SVRn club!
Hi Gaj,
You are right, chart for GT3 where Ledipasvir is x1000 less effective compared with Daclatasvir!
Tiny quantity of active substance
1 Mol = 1 M = 6.02 x 1023 moleculesand in the chart are nM = 10-9 or pM = 10-12
Thanks for the explanation!
”James-Freeman-facebook” wrote:The key point is the the CREATION of resistance requires replication, so it happens BEFORE treatment starts unless we don’t get good viral suppression and replication continues.
When we treat we kill of the easy to kill virus and suppress almost all replication. With no replication there is no opportunity for a mutation to form.
Virus that already existed, that is resistant will not be killed efficiently, although it’s growth will not be helped by the drugs. Nevertheless it will survive and when we remove the drugs it grows back. Now we can see it and measure it, but it was not created by treatment. It existed before we started.
The reason for waiting to retreat is, to me, not to wait for RAVs to fall to levels we can’t measure. They will still be there, probably forever. It is to wait for access to more powerful drugs, or preferably extra agents
The advantage of a 3rd agent
RAVs deliver a 10x 100x or even 1000x resistance to drugs. What this means is that the EC50 (Effective Concentration to kill 50%) of a better drug needs to be 10x + to make a real difference. Let’s look at GT3 EC50:
Conclusion: 3 drugs beats 2 drugs.
Thanks dr. Freeman for more info!
I have a question, please. What does nM respectively pM unit of measure stands for? M is mol of substance, chemistry?
However, Ledipasvir versus Daclatasvir … I was very lucky to be cured with Ledipasvir. It’s great that there are already solutions for those who have not succeeded yet, Velpatasvir and Viekira-pak.
But the results for ABT-493 and ABT-530 are even more spectacular.http://www.ncbi.nlm.nih.gov/pubmed/27456384
Good luck, good health and only UND to everyone!
fitz wrote:Yesterday was my last dose of generic Sof/Led obtained through the REDEMPTION 3 Trial. 6 weeks since VL <15, and 4 weeks since UND.
Today is EOT for me, and it feels a bit surreal not to have opened the bottle of MYHEP LIVR -- Generic 'Harvoni' Sofosbuvir 400mg, Ledispavir 90mg produced under Gilead license in India by Natco for Mylan. The medicine bottles are now quite empty, there is no medicine left. I have taken the entire 12 week course of treatment. I'm done.
Happy EOT and only UND!
I have relied on human curiosity and was fine.
In 2010 I was diagnosed with hepatitis C and F0/F1. I waited two years, until 2012, the treatment with interferon. And I refused the interferon!
My decision was easier to take because of a great GI doctor, at the end of the career (70 years). He encouraged me that soon there will be other less invasive options than interferon + ribavirin. The GI doctor whom I refused the interferon indication was not happy but accepted my decision and I just made annual bloods and tests echography / fibroscan.
In 2015 I explained my GI doctor that I want to treat my HCV but not with interferon. The treatment with DAA was and is still available only for F4. So I said I want / can buy HARVONI. Of course he was surprised and asked me if I knew how much it costs 44 000 Euro = 50 000 USD. My response was that I am trying to get the money.
So I asked him if it is possible to give me the prescription for HARVONI, to monitor me during / after treatment and what other bloods / tests to do. I did the bloods / tests. When I received the prescription, I remembered once again, that the active substances must be specified, SOFOSBUVIR and LEDIPASVIR, like any prescription. I translated the prescription in English at an authorized translator. With this prescription I was in Bangladesh, at Incepta factory, and got medication for 12 weeks, according to medical indication. It was the end of November 2015, and India was still not selling generic medication for HCV.
The doctor said YES!
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hmy: 
My GI doctor told me to come to him before the start of the treatment. So I immediately began the treatment.
On the visit I made to the GI doctor, I informed him that I had money only for TWINVIR, generic Harvoni and that I have already begun the treatment and I feel very good. I gave him the link to FixHepC. He saw that a doctor in Australia have tested the medicine and is identical to the original and all your success stories with generics!From now on our collaboration worked well, within the limitations of NHS in my country! Although he was not happy with my decisions and I forced his patience, the curiosity won.
When I had clear results, the GI doctor asked me details. I was the first patient treated with generic medication for hepatitis C in that clinic. I gave the link to all patients / doctors / nurses who wanted to know more. I spoke with everybody who contacted me for more details.
From my point of view, in my country, Romania, the patient must have the initiative if is not F4 and don’t want interferon treatment. He must be determined. There are good GI doctors that are willing to help you!
But in order to be determined you must have access to information, basically the internet and English language.
This was my advice if the person is not used with the internet nor with English language. Everybody have a child or a brother or a nephew or a friend or an acquaintance that can give you the information you need to be determined.I wish you good health and good luck to all sufferers, including those with hepatitis C!
tweakmax wrote:My doc didn’t order SVR24 VL test for me, only fibroscan. She seemed confident about the “cure”.
Hi tweakmax,
You already had a happy SVR12 so I wish you a happy SVR24 and only UND!
We are waiting for you in the SV24 club!
