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Well I just had to throw a comment bomb over there too! If it is to get people to talk about generics, research about the trials and get cured – it is worth a ” comment bombardment” friends!
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hello there rightsaidfred! Thanks for the link to the cool MRI scanning. So great to be able to see your liver in such detailed ways! Best of luck to your SVR 4!
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
YES!!!
Best news possible upon landing from a long flight!
It made my day!
Big smile here, this is really awesome fitz!
Congratulations my friend.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
9 August 2016 at 1:10 am in reply to: Just emailed dr Freeman about fixing my father-in-law’s HepC #21991Hi Cadu so happy you are here with us! Your father in law will get the best treatment through Dr Freeman and will join our SVR “club”! Best of wishes and big abraço to you!
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hi again! Going back to the original topic I just saw on a facebook Hep C forum that someone who thought had relapsed at SVR12 is now UND at SVR24! Something Dr Freeman said at the time – about two months ago- to wait until next bloods to make sure it was really a relapse. It wasn’t. Such happy news I just had to share it here. Also a good example (there must be lots and lots) that it is better not to rush into re-treatment – unless there is a F4 and psychological aspects that Dr Freeman mentions in his OP.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hi Gaj I hear you! Yes I have spoken to my GI in Brazil as well as to Dr Freeman ( on a GP2U consultation) and both have told me that since I already have the third bottle of generic harvoni with me and unless I develop real bad sides from now on (I complete 9 weeks of tx tomorrow) It is better to do the 12 week tx – in spite of meeting the 8 week guidelines – as an insurance and reassurance of SVR. So I cut a deal with myself so to speak and I will play by ear and see how my 9 week labs and ultrasound results will come out next week. I am very curious specially about level of fibrosis – if it had a regression. Thanks again for “following” up on me and all your support.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hi Gaj thank you so much for explaining how Sofosbuvir S282T resistance goes and how rare it is to become resistant to Sofosbuvir. Phew! I had no idea. Also have been biased all along by “the desire to reduce length of exposure which is a worthy aim with any drug as long as the Tx is effective” . I have missed this other very important piece of information too that “the 95% SVR rate we talk about for 8 weeks harvoni Tx will actually increase to something like 99% if 1b patients are given 12 weeks Tx.” ! This is fantastic! hmy: As far as I had understood so far it was just about 1% increase. Lastly I had no idea either that a 8 week tx could in fact increase the risk of resistance comparing to a longer tx. Live and learn everyday!
Thanks again Gaj.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Very interesting thread!
Tweakmax you wrote : ” But would there be resistance e.g. worst case is sofosbuvir resistance at position S282T, then it will definitely affect future treatments as sofosbuvir is still the backbone for HCV treatment/retreatment
” .Does it mean that longer treatments with sofosbuvir may cause the Hep C virus to become resistant to it? What comes to mind is when treating G1b – no cirrhosis – tx naive – low VL it would be the ideal to treat it with 8 weeks instead of 12 weeks following Gilead’s guidelines. Because if there is a relapse – and 5 % will relapse anyway no matter how well patients follow any specific tx (it is a matter of statistics) there is smaller chance to become resistant to sofosbuvir on a 8 week tx than on a 12 week tx. Right?
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hi everyone. From what I have observed and known of you guys – we are pretty much free and independent thinkers (kind of rebels actually ) who do our own research and go after solutions and answers to challenges (such as relapses), differently than most of the population who waits – sometimes in vain – for a miracle to descend upon us. We all “have been around” and as grown ups with plenty of life experience I am sure we would not follow any a ” tip” without a thorough analysis, research and talking to our doctors first. Having said that I see no danger in us discussing the benefits of adding Chlorcyclilzine in our regimen, specially as someone else has mentioned even Dr James Freeman thought about it already. It might be that it will indeed give a hand to the DAAs by stopping the Hep C virus to re-enter the cells and increasing our chances to SVR. So if you Fitz want to be the “guinea pig” illy:' /> in this experiment, you have all it takes to. I trust your discernment!
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
I know it is a lay man conjecture but it makes sense. I am just not clear how the dosing is . If it is drowsing than a different one should be taken during the day. I actually like the idea of taking them at night but not being dizzy during the day. In any case I think your find is brilliant. hmy:
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Wow Fitz what a great research! Thank you. I am now totally intrigued and curious about your find. It might help falling and staying asleep too as an extra bonus. Btw I heard that Vitamin B12 is good to improve SVR chances too. Will check the links you posted.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Yay good to know! Thank you so much for your input Dr Freeman.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
25 July 2016 at 2:22 am in reply to: Italy – on the path to open the gate for HCV generic drugs #21358Thank you for the share RHF! Brazil sooo should follow on Italy’s steps to opening up the gates for generic DAAs!
Edit: I mean on a governmental level so pharmacies here could sell them too. It is already legal to import medication for personal use.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
OUCH! Sorry you had to go through all those surgeries Fitz. Had no idea how serious it was. hmy: Thank you so much for sharing the images. Now I get it!! For sure it will help anyone on the fence to make the decision to treat Hep C asap.
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
Hi Gaj it was only last night that I started catching up with this thread. Until then I had no idea you had relapsed. I am so sorry about it. At the same time I am impressed by both your positive attitude and the level of care and love shared herein by everyone who knows you. It came to my mind also – that DAAs have indeed given us all a ” break” (interlude) from Hep C and if I were to relapse too – I would have been happy just by the very fact that for few weeks I felt well and “normal” again. Good to hear you are stronger physically and that you are determined to keep up with a good diet and plenty of exercise. And hey…you will SVR at some point as everyone has already mentioned here because the DAA industry won’t leave Gt3s alone!! We will all make sure of that!
Big hug from Brazil!
Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)SVR 4 Virus UND (September 7th)
AST 13 – ALT 5SVR 14 Virus UND (November 12th)
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