Hi,
The ledipasvir needs an acidic environment to breakdown and be absorbed properly. So, acid reducers 4 hours before or after dosing. According to Harvoni packaging info, omeprazole (Prilosec) should be avoided, famotodine (Pepcid) is not mentioned.
Makes sense, since Prilosec takes a while to begin to take effect.
I was taking both and another custom compounded med for my horrible dyspepsia. It gradually got better after a year of no alcohol and animal fats. I love bacon. It was guaranteed to give me violent reflux, bloating, nausea and belching this tasteless white foam. It got so bad, I would eat food one day, knowing I would be up all night with dry heaves and reflux you could choke on. Then totally fast the next day and get some sleep. I had two endoscopies to determine the cause. Gastritis. I was a regular drinker with a cast iron stomach until I turned 60. Then, BOOM! Then best relief was to walk. Walk until the food and foam settled. I walked a thousand miles that horrible year, mostly at 2 or 3 in the morning. Good news is no high blood pressure and a resting HR of 50bpm.
So, I haven’t had any problems at all, during or after tx. I do have a beer along. One very good, locally made, very tasty, very potent bottle of Farmhouse Ale.
I don’t think I will ever be able to eat bacon again. The thought of driving the porcelain bus pops up every time I see or smell it.
Oh well, I’m sure the pigs are happier!
Mike

http://hepatitiscnewdrugs.blogspot.com/2016/02/his-job-is-to-sell-1000-pill-for-10.html?m=1

Gilead has a “very sophisticated strategy,” says Tahir Amin, co-founder of the nonprofit group Initiative for Medicines, Access and Knowledge. The company has excluded Chinese generic-makers that could have hastened delivery but would have cost Gilead profits, Amin says. And Gilead “could certainly do more” for middle-income countries not among the 101, he says, singling out China, Brazil and Ukraine, where the disease-burden is high…….

I had major problems sleeping as well.
Stress and worry, HCV, stomach issues and rage at a broken system combined to make sleeping very hard.
Lack of sleep left me a walking, fatigued zombie.
The whole time seems like a nightmare now.
It’s over for me.
Soon it will be for you as well.
M

Here we are, posting on a site that was founded because the health care systems where we all live are broken. So, “What is the perfect medical treatment system?” That is a good question.
The answer can be different for each person who is asked. Maybe one group from one country like theirs and another, from the same country, hates it. Could be what works well in a densely populated nation would suck in a place less crowded.
Defining the qualities of a good system are easy: Accessible, affordable, fair, cost-effective, quality medicines, skilled and compassionate doctors, etc. But different countries have to adapt to their unique conditions.
So, in short, it’s like asking what came first, the chicken or the egg? But, maybe you live in a place where that isn’t a relevant question, because the government tells you which came first. Perhaps there are no chickens where you live, so you really could care less.
I think I will focus my limited intellect elsewhere, as this discussion seems to be an argument waiting to happen.
If I have offended anyone, I am truly sorry.