Darbara.
I am f3/f4.I am into wk 11 of Sof Dac Riba.I have elected to add another 12wks of sof dac(if it arrives in time from the Buyers Club) and another 6 wks of Riba,(which is when my Riba supply runs out,I don’t want to have to buy any more,and I fall a couple of wks short of it being on the PBS).
So that will make a total of 24wks of sof dac and 18wks of riba.
According to the EASL guidelines this is overkill.According to the AASLD guidelines its what is required.From the experts I get a mishmash of opinions.I want to be in the 95% plus success cohort.The Riba hasn’t been kind at times,but it hasn’t clipped my wings at all.My partner often asks when is she going to get the real Miko back.
What has been my biggest encouragement is a guy up the street that is 10yrs younger than me and who has Parkinsons Disease.I often see him painfully shuffling down to the shop.I look at his agony and think “what the hell have I got to winge about,at least I have a good chance of a cure,He has none.”
It is amazing how quickly time passes.It’s so little to put up with for so much to gain.
Go for the max Darbara and cut down your risk of failure to the minimum,and don’t even contemplate failure..

So how does anyone other than the fund manager know how much is in it?
Just curious,as it is an interesting social experiment.

“If it comes back just hit it again?” Just up the dosage?” etc. and she said yes, you’d basically just need to hit it harder for longer”

Thats only an option for a very select group of people.If a health service is paying,forget it.Even with generics it would be pushing the financial limits for a lot of people.
With a 24 wk tx length is there any evidence of the efficacy of changing regimes at the 12 or 16 wk mark?It is probably something that the drug companies would resist trialling for commercial reasons.

Gaj
I think this guys opening statement says it all.Its still” have a good guess ,and take your chances science.
In my own case the IDSP recommendations are as confusing and different as the EASL Guidlines.

https://www.youtube.com/watch?feature=player_detailpage&v=oKeYXZjw9Rc

Well that explains why the original 6mg of dac I got off Mesochem made the 100 capsules I got back from the compounding chemist.
I wonder why a competant compounding chemist didn’t pick up on that one as Declatasvir Hydrochloride was on the sealed packet?
Anyway I still got virus undetected at 4wks on the lowered dose,in case anyone else is panicking.

Do in time
You are making too many quantum leaps here to answer one by one.
It is true Gilead has no obligation to lower its price.Corporations Law requires a company to maximise it’s profit in the interests of its shareholders.Its not just Gilead.I have seen how agricultural chemicals banned in the first world are actively promoted in the third world.I have seen stacks of new asbestos roof sheeting in warehouses all across south east asia.Asbestos kindly supplied by Canada,with the excuse that if they don’t ,it will get sourced from Kazakhastan,so we might as well get the money.I have seen children playing in the dust of broken sheets,The promotion of sugar products,and the subsequent diabetes 2 epidemic far overshadows Hep C.The list goes on and on.And don’t even start on tobacco.
Corporations are as ruthless with each other as they are to their clients.It is a ruthless,merciless system that hides behind such meaningless epithets such as “Freedom,human rights,democracy”,and bomb into oblivion anyone that gets in the way.
Kindness,generosity,decency,have no place in their world.What they are doing cannot be considered a “war crime” because there is no defined war as such The rare Jonas Salk’s of the past are looked on as foolish abberants.And therein lies the problem.It is an human ethical problem for which there are not and can never be any laws.
As human beings we have an obligation to be nice to each other.It is incumbent on the ultimate survival of the human species.But no law can ever enforce this.If a car driver comes across a crashed cyclist bleeding to death on the side of a lonely road and says yes I will help you,but first sign over all your worldly belongings to me,he is probably not breaking any law,but if found out,would have to endure the derision and scorn of all decent people.Look what happened to that idiot dentist that shot the Lion in Zimbabwe.
And that really is the answer with Gilead.Hold it up to scorn and derision.Throw every kind of abuse possible at its lack of ethics.Support countries that say that when it comes to a life saving drug,stick your patent up your “fat corporate asses”Do what Greg and Dr Freeman,and all the others are doing and find ways of circumventing the process.It is the only real weapon.
Use any means legal or otherwise of breaching their defenses.
My real hope is that someone will come up with a biosimilar,which will really send them screaming in agony.I believe some European group is already searching 3000 existing molecules to find an effective replacement for sovaldi.

emilio in an earlier post of yours.

” Talking with rachel from mesochem now to see if I can get 1/2 batch if not I’ll order a full course and go from there. . Em ”

How did you go with this enquiry,as I note you were at the time considering extending your tx to 18wks.
I am doing the same .Through circumstances too long winded to explain I am short 42 days of Sof,21 days of dac,and 18 days of Riba.
All quotes I have got (except for Mesochem),but including the Buyers Club,and Aust compounding chemists.resulted in prices that were so close to the 12 wk prices that I may as well get the 12 wks which will leave me with a heap to give/throwaway,which seems a waste.