Hi Re-roll,

You’re right, I didn’t post exact numbers for the booze. On a beer-day, it is typically 3 small beers (3×1.3 = 4 UK units) or 1/2 bottle of wine (4.5 units). On a non-beer day it is 0 or 1 small beer (yes, I know!…. I have had several party-nights, maybe about one every three weeks recently where we go out or have people in. Always a lot of empty wine bottles afterwards! But always spread over the whole evening, and always with lots of food. These days, I am very aware that after such evenings I am in amazingly good shape the next morning, compared a year ago I would have been wiped out the next day (in fact, a year ago, I only ever had a glass or two at parties because I knew that otherwise I would pay for it afterwards….

Putting it all together, I am probably drinking at least something on 5 or 6 days out of 7, and averaging about 25-28 units per week. I believe most doctors in the UK recommend not to regularly exceed 28 units/week. So I think am within “safe” limits.

Anyway, at first, I put all my figures in a table just for myself because it helps to show up any trends. And then, why not just put them all on-line? Many of us put the key numbers in our signatures anyway…

Maybe now we take it for granted that many people will get to <15 or UND at 4 weeks. But what really surprised me was that while 6 months off the booze last year brought down the GGT by about 15 points to 50 (almost touching "normal"), just 3 months of Sof+Dac(+Booze) dropped the GGT by an additional 20 points down to 30.

In the FAQ (http://fixhepc.com/kunena-2015-11-10/faq.html), it says that "GGT will probably remain elevated if you are drinking during treatment, but that's the booze not the bug."

In my own little experiment (n=1), it certainly looks like its the bug, not the booze…

Anyway, here’s to sensible drinking…

Cheers,

Great stuff, Joy! This is how it should be!

He-he!! Imagine if just one spliff is all it took for all the JWs in the world to turn Rasta and go around knocking on doors to spread the Hep-C word!?

“Honey, You know I gave up cigarettes for my New Year’s resolution, but I ain’t never going to give up smokin”

Gee, I hope I don’t get banned for posting this. I would miss all you guys and gals!

Yeah, seconded.

Please can someone change the title of this thread to “Prof Gane’s remarks: implications for total recovery”, move it to the “Don’t Worry” archive, and then close it from further posts?

Hi Folks,

It seems like a lot of people are getting worried about that remark from Prof Gane about the *possibility* of relapsing with certain generics.

Dr James has verified by NMR that all the generics sourced by the FixHepC Buyers Club and that the generics manufactured by the companies recommended on the FixHepC web Forum are chemically equivalent to the patented molecules:

http://fixhepc.com/blog/item/16-testing-provisions-patient-safety.html

This means that apart from a few minor (and probably irrelevant) arguments about solubility and kinetics, Dr James has done everything humanly possible to show the generics that we all are taking may be assumed to be bio-equivalent to the patented molecules.

As several other people on this thread have already pointed out (mgalbrai, Price, Sirchinenge, GAJ, …, you just need to look at our forum signatures to see that the FixHepC generics are working extremely well. This is overwhelming evidence that there is no difference between the FixHepC generics and the patented molecules. The NMR spectra say we are taking the correct molecules. All the results posted so far say we are taking the correct molecules. So do not worry, do not fret! Molecules do not know about nationality or packaging. All the evidence so far says that the molecules made in China, India, and Bangladesh are the same molecules as the molecules made for Gilead in Ireland.

Here are some results posted previously by Dr James from previous trials using molecules made in the USA or Europe:

http://fixhepc.com/forum/questions-and-answers/644-query-8-week-protocol.html?start=6#9804

Probably a lawyer would say that NMR doesn’t prove bio-equivalence… The final proof will be the results from the REDEMPTION trials. I am sure that once the results are in they will show comparable or better statistics. Probably better because REDEMPTION will be the biggest trial ever.

Personally, I am already absolutely convinced that the generics I have been on are bio-equivalent. But I am a chemist, not a lawyer. REDEMPTION will provide the ultimate proof.

So for what its worth, my advice about the risk of relapse is this – DON’T WORRY, IT WILL PROBABLY NEVER HAPPEN.

But even if the worst does happen, it will be just bad luck and nothing to do with which little country (joke) you got your treatment from.

Yours,

Oor Wullie

(Expert in Catapults and Chemistry)

Thanks Mike,

But why are CBS going after Schinazi so hard?

Because he once worked for the VA?

Or is it because he made $400M when Pharmasset was sold to Gilead for $7Bn? If Schinazi got $400M out of the deal, it makes him only a 5% share-holder in Pharmasset. Scarcely a position of power, and certainly not in a position where he have any say in the matter. After all, it is Gilead who are doing all the price-gouging … to the tune of $21Bn per year on Sovaldi alone…

At first sight, it seems to me like CBS are missing the real culprit… What are they afraid of?

On the other hand, maybe the fact the Schinazi worked for the VA is ultimately the best way to attack patent and pricing issues. If Schinazi worked for the VA, then the VA should get a fair percentage of the rights to any intellectual property (IP) he generates.

In the UK and most of europe, it is quite normal for a university researcher to be obliged to hand over to his employer ALL the intellectual property that he might produce – usually in return for a gratuity of 30% (say) of any eventual commercial success that might arise.

In the UK at least, if Schinazi was also working for an outside company (i.e. Pharmasset), he should have declared this to his employer (i.e. the VA), and cut a deal. And if he didn’t, he was most probably in breach of his contract with the VA. Either way, on this basis, the VA should have a rightful claim on a good percentage on Schinazi’s IP. In short, the VA should own most of the rights to Sofosbuvir, and could potentially file a massive claim against Gilead…

Go VA!!

More on Pamela Anderson… She is cured of hepatitis C, so what is she doing now?

Pamela Anderson Lends Star Power To Fight Against Foie Gras In France!

http://www.npr.org/sections/thesalt/2016/01/20/463680865/pamela-anderson-lends-star-power-to-fight-against-foie-gras-in-france

“In many national cultures, there seems to be at least one cruel tradition that stands out as identifying that culture,” said Anderson. “Be it the bullfight in Spain, eating dogs in Korea, the slaughter of dolphins and whales by Japan or the bloody and obscene massacre of seals in my own native Canada.”

Yeah, right, Pamela. I’m all in favour of animal rights. But what about human livers? There are approximately 4 million in the USA and 750 million world-wide that could easily be saved?