Hi Live life

I am glad you posted this because I also have questions about encapsulating the Mesochem APIs.

1.
What size capsules are needed for 400mg sofosbuvir / 60mg daclatasvir?
2.
I am doing it myself and I understand that fillers are not required. Is that correct?
3.
Once encapsulated, do the capsules need to be stored in the fridge? Once stored correctly, can they be expected to remain viable for 6 months from date of encapsulation, provided that the dry bag of powder as shipped had an expiry date of at least one year?

Thanks,
dointime

Hi

I will wait for the good doctor to answer this however I’ve had the same conversation with him at my last skype visit. Apparently there are options here but best to use a vegetable extract filler and can be compounded using digital scales and filler kits. Really fiddly but can be done, for $70AU I’m having mine done by a compound chemist. Re the filler name eludes my brain atm and with these drugs there is no need to use with fats for better absorption like with ribavirin and other meds, that’s assuming you’re not using ribavirin.. Storage I believe is room temperature within reason but like I said, James will get back to you on this. Em

I put daclatasvir and sofosbuvir together in the same capsule, whether it is a problem?????

I just thought I’d have to throw it and buy a new API

We have been doing accelerated stability testing on this and it seems fine.

Do not worry, as soon as medications arrive in stomach they mix freely anyway.

Emilo I mix 400 sof 60dac before capped.tnx

We have seen quite a lot of their product from at 6 different batches (when last I looked) and it has been consistently good in terms of closely matching our reference standards.